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GlossaryHyperkeratinization

excessive keratin production leading to thickened skin patches

Hyperkeratinization is a condition where there is an excessive production of keratin, a protein that helps form the outer layer of the skin, hair, and nails. This overproduction can lead to the thickening of the skin and the formation of rough, scaly patches, and is often associated with conditions like acne, psoriasis, and certain types of alopecia.

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The Evolution of Healthy Skin to Acne Lesions: A Longitudinal, In Vivo Evaluation with Reflectance Confocal Microscopy and Optical Coherence Tomography

research The Evolution of Healthy Skin to Acne Lesions: A Longitudinal, In Vivo Evaluation with Reflectance Confocal Microscopy and Optical Coherence Tomography

19 citations , April 2019 in “Journal of the European Academy of Dermatology and Venereology”

Acne lesions start with changes in hair follicles and increase in inflammation, suggesting a cycle that could affect treatment strategies.

research 5-Bromo-2′-Deoxyuridine Induced Effluvium via p53-Mediated CD326-Positive Keratinocyte Apoptosis in C57BL/6 Mice

August 2016 in “Journal of Dermatology”

A chemical called 5-Bromo-2′-deoxyuridine caused rapid hair loss in mice by killing certain skin cells through a specific cell death pathway.

research Etiopathogenesis of Acne

February 2006 in “Expert review of dermatology”

Acne is caused by hormones, genetics, skin cell buildup, oil production, bacteria, and inflammation.

research Acne Syndromes and Mosaicism

1 citations , November 2021 in “Biomedicines”

Understanding how acne develops in different diseases could lead to new treatments.

research Meibomian Gland Changes in the Rhino Mouse

48 citations , July 1988 in “PubMed”

Rhino mice show significant meibomian gland changes, making them a potential model for studying gland disorders.

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community If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

nkrata in Research 830 upvotes 1 year ago

Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.