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    Glossary Hyperkeratinization

    excessive keratin production leading to thickened skin patches

    Hyperkeratinization is a condition where there is an excessive production of keratin, a protein that helps form the outer layer of the skin, hair, and nails. This overproduction can lead to the thickening of the skin and the formation of rough, scaly patches, and is often associated with conditions like acne, psoriasis, and certain types of alopecia.

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      Updated Treatment for Acne: Targeted Therapy Based on Pathogenesis

      research Updated Treatment for Acne: Targeted Therapy Based on Pathogenesis

      78 citations , June 2021 in “Dermatology and Therapy”
      This study highlights the evolving understanding of acne's pathophysiology and suggests that targeting pro-inflammatory cytokines such as IL-1β, IL-17, IL-23, and TNFα with biological antibodies may offer new treatment strategies for severe acne and its scars.

      research Zinc Deficiency in Suckling Mice Deprived of Colostrum

      53 citations , January 1953 in “˜The œjournal of nutrition/˜The œJournal of nutrition”
      This study found that newborn mice deprived of colostrum developed disorders linked to zinc deficiency, and administering inorganic zinc prevented these conditions.

      research Meibomian gland changes in the rhino (hrrhhrrh) mouse.

      48 citations , July 1988 in “PubMed”
      In this study, researchers observed that rhino mice exhibit significant ductal hyperkeratinization in the meibomian gland, which may represent the first naturally occurring disorder of this gland in mice.

      research Fibroblast growth factor and epidermal growth factor in hair development

      39 citations , July 1993 in “˜The œjournal of investigative dermatology/Journal of investigative dermatology”
      This study found that daily injections of basic and acidic fibroblast growth factor in newborn mice significantly delayed hair follicle development within the treatment area, while epidermal growth factor affected the entire body coat and caused skin hyperkeratinization.