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GlossaryHyperkeratinization

excessive keratin production leading to thickened skin patches

Hyperkeratinization is a condition where there is an excessive production of keratin, a protein that helps form the outer layer of the skin, hair, and nails. This overproduction can lead to the thickening of the skin and the formation of rough, scaly patches, and is often associated with conditions like acne, psoriasis, and certain types of alopecia.

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research Updated Treatment for Acne: Targeted Therapy Based on Pathogenesis

78 citations , June 2021 in “Dermatology and Therapy”

Future acne treatments should aggressively target inflammation to prevent scarring.

research Pathways to Inflammation: Acne Pathophysiology

68 citations , May 2011 in “European Journal of Dermatology”

Acne is caused by genetics, diet, hormones, and bacteria, with treatments not yet curative.

research Zinc Deficiency in Suckling Mice Deprived of Colostrum

53 citations , January 1953 in “The journal of nutrition/The Journal of nutrition”

Newborn mice need colostrum for zinc to grow normally.

research Fibroblast Growth Factor and Epidermal Growth Factor in Hair Development

39 citations , July 1993 in “The journal of investigative dermatology/Journal of investigative dermatology”

FGF and EGF are crucial for hair follicle development and growth.

The Evolution of Healthy Skin to Acne Lesions: A Longitudinal, In Vivo Evaluation with Reflectance Confocal Microscopy and Optical Coherence Tomography

research The Evolution of Healthy Skin to Acne Lesions: A Longitudinal, In Vivo Evaluation with Reflectance Confocal Microscopy and Optical Coherence Tomography

19 citations , April 2019 in “Journal of the European Academy of Dermatology and Venereology”

Acne lesions start with changes in hair follicles and increase in inflammation, suggesting a cycle that could affect treatment strategies.

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community If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

in Research 830 upvotes 1 year ago

Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.