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    Glossary Keratinocyte Hyperproliferation

    rapid and excessive growth of skin cells

    Keratinocyte hyperproliferation refers to the rapid and excessive growth of keratinocytes, which are the primary cells found in the outer layer of the skin. This condition is often associated with skin disorders like psoriasis, where the skin cells multiply too quickly, leading to thick, scaly patches.

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    1. Expression of involucrin in normal, hyperproliferative and neoplastic mouse keratinocytes Experimental Dermatology · 2000 · 58 citations
    2. No evidence for follicular keratinocyte hyperproliferation in acne lesions as compared to autologous healthy hair follicles Experimental Dermatology · 2018 · 7 citations
    3. Dandruff Is a Low‐Grade Inflammatory Condition Featuring Hyperproliferative Keratinocytes, Interleukin‐17‐Producing T Cells, and N‐Acyl Ethanolamines Immunity Inflammation and Disease · 2026
    4. Keratinocyte-specific ablation of the NF-κB regulatory protein A20 (TNFAIP3) reveals a role in the control of epidermal homeostasis Cell death and differentiation · 2011 · 76 citations
    5. The role of Glucosylceramides in Keratinocyte Differentiation and Epidermal Barrier Function 2013 · 1 citations
    6. Keratinocyte differentiation in psoriatic scalp: morphology and expression of epithelial keratins British Journal of Dermatology · 2006 · 63 citations
    7. CtBP1 Overexpression in Keratinocytes Perturbs Skin Homeostasis Journal of Investigative Dermatology · 2013 · 9 citations
    8. Abstract 5357: Targeting mTORC1 suppresses proliferation of keratinocyte stem cells and inhibits skin tumor promotion in mice Cancer research · 2014
    9. Embryonic NIPP1 depletion in keratinocytes triggers a cell-cycle arrest and premature senescence in adult mice Journal of Investigative Dermatology · 2024
    10. Keratinocyte-derived follistatin regulates epidermal homeostasis and wound repair Laboratory investigation · 2008 · 28 citations
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