No Evidence for Follicular Keratinocyte Hyperproliferation in Acne Lesions Compared to Autologous Healthy Hair Follicles

March 2018 in “ Experimental Dermatology ”

Gabriella Persson, Emma Johansson‐Jänkänpää, Rūta Gancevičienė, Ayşe Serap Karadağ, Serap Güneş Bilgili, Hélène Omer, Oleg A. Alexeyev

keratinocyte acne vulgaris hair follicles immunohistochemistry immunofluorescence microscopy Ki67 phospho-histone H3 apoptosis cleaved-PARP hyperkeratinization

TLDR Acne lesions don't show increased keratinocyte growth compared to healthy hair follicles.

The study investigated the role of keratinocyte hyperproliferation in acne vulgaris by examining 66 patients. Researchers assessed markers of proliferation, mitosis, and apoptosis in acne lesions and compared them to unaffected hair follicles from the same patients. The results showed no significant difference in the expression of proliferation markers, such as Ki67 and phospho-histone H3, between acne lesions and control follicles. Additionally, apoptosis marker cleaved-PARP was rarely expressed. These findings indicated that increased keratinocyte proliferation was not present in acne vulgaris, suggesting that other mechanisms might be responsible for the hyperkeratinization observed in acne pathogenesis.

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