Androgens Modulate Keratinocyte Differentiation Indirectly Through Enhancing Growth Factor Production From Dermal Fibroblasts

    January 2019 in “ Journal of dermatological science ”
    Chanat Kumtornrut, Takeshi Yamauchi, Sumie Koike … Kenshi Yamasaki
    Studysummary This study suggests that androgens enhance growth factor production in dermal fibroblasts, which in turn may alter keratinocyte differentiation and contribute to acne lesion formation.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
    Read the full study on jdsjournal.com →
    Discuss this study in the Community →

    Research cited in this study 11

    1. No Evidence for Follicular Keratinocyte Hyperproliferation in Acne Lesions Compared to Autologous Healthy Hair Follicles Experimental Dermatology · 2018
    2. Androgens and Androgen Receptor Action in Skin and Hair Follicles Molecular and Cellular Endocrinology · 2017
    3. Sex Hormones and Acne: The Role of the Skin as an Endocrine Organ Clinics in dermatology · 2016
    4. Hormonal Therapies for Acne Clinics in Dermatology · 2016
    5. Evidence-Based Approach to Cutaneous Hyperandrogenism in Women Journal of The American Academy of Dermatology · 2015
    6. Polycystic Ovary Syndrome: A Review for Dermatologists Journal of the American Academy of Dermatology · 2014
    7. Polycystic Ovary Syndrome: A Review for Dermatologists Journal of The American Academy of Dermatology · 2014
    8. Role of FGFR2-Signaling in the Pathogenesis of Acne Dermato-endocrinology · 2009
    9. Localization of Sex Steroid Receptors in Human Skin PubMed · 2004
    10. Lack of Androgen Receptor Transcriptional Activity in Human Keratinocytes Journal of dermatological science · 2000
    11. Androgen Receptor Antagonists Structure-Activity Relationships Current Medicinal Chemistry · 2000