TLDR Leptin affects skin and hair health and may worsen some skin conditions, but more research is needed to understand its full impact.
The document from 2020 reviewed the role of leptin in skin diseases, emphasizing its involvement in psoriasis, hair growth, and other conditions. Leptin, produced by white adipose tissue, functions as a hormone and cytokine, influencing skin physiology and pathology. It was found to stimulate angiogenesis, produce pro-inflammatory cytokines, and potentially activate the anagen phase in hair cycles. Higher serum leptin levels were observed in obese patients with psoriasis, and leptin's pro-inflammatory activity may exacerbate this condition by stimulating the Th1/Th17 axis. The review also noted leptin's association with male androgenetic alopecia, with higher BMI correlating with increased severity of hair loss, and higher serum leptin levels in AGA subjects. However, leptin levels were not linked to AGA severity. In atopic dermatitis, leptin levels varied and were inversely correlated with disease severity in some cases. The document concluded that leptin has confirmed effects on skin and hair but requires further research to fully understand its role in skin disorders. It also suggested that obesity treatment could improve skin conditions, as no leptin-oriented medication is available.
8 citations,
April 2017 in “Experimental Dermatology” More plasma leptin means higher baldness risk in men.
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25 citations,
March 2014 in “Experimental Dermatology” Leptin helps start the growth phase of hair.
41 citations,
November 2013 in “Experimental Dermatology” Leptin, a hormone, is important for starting hair growth.
38 citations,
November 2013 in “Journal of The American Academy of Dermatology” Higher BMI links to worse hair loss in Taiwanese men.
20 citations,
July 2013 in “International Journal of Dermatology” Obesity increases the risk of skin infections, inflammatory conditions, and melanoma, but not basal cell carcinoma.
81 citations,
December 2009 in “Journal of Dermatological Science” Fat tissue stem cells may help increase hair growth.
31 citations,
November 2020 in “International journal of molecular sciences” Adipokines affect skin health and could be targeted for treating skin diseases.
51 citations,
July 2010 in “Trends in Endocrinology and Metabolism” Prolactin may play a significant role in skin and hair health and could be a target for treating skin and hair disorders.
15 citations,
February 2021 in “Frontiers in immunology” Leptin, a hormone from fat cells, affects immune responses and can influence skin diseases and hair growth.
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January 2019 in “European journal of histochemistry” Cattle skin has leptin which might control skin and hair growth.
42 citations,
May 2016 in “Annual Review of Cell and Developmental Biology” Fat cells are important for tissue repair and stem cell support in various body parts.
