Leptin and the Skin: A New Frontier

The document explored the role of leptin, an adipokine, in the biology and pathology of mammalian skin and its appendages. It highlighted leptin's potential to improve skin regeneration, hair cycle progression, and possibly reverse aspects of skin aging due to its ability to enhance mitochondrial activity and biogenesis. Leptin's intracellular signaling pathways, involving Janus kinase 2, signal transducer and activator of transcription 3, adenosine monophosphate kinase, and PPAR gamma coactivator, were noted for mediating mitochondrial activation and cell proliferation. The study suggested that leptin and its mimetics, which had been clinically tested, could have significant dermatological applications, warranting further exploration in investigative dermatology.