TLDR L-Carnitine-L-tartrate may help hair grow and prevent hair loss.
The study from 2007 explored the effects of L-Carnitine-L-tartrate (CT) on human hair growth in vitro. Human hair follicles in the anagen VI stage were treated with various concentrations of CT for 9 days. The results indicated that low concentrations of CT (0.5 µM and 5 µM) significantly stimulated hair shaft elongation and prolonged the anagen phase, while higher concentrations (500 µM) were inhibitory. CT also reduced apoptosis and upregulated proliferation in hair matrix keratinocytes, and downregulated factors associated with the transition to the catagen phase. The study concluded that CT has the potential to be used as a treatment for hair loss conditions by promoting hair growth and delaying follicle regression.
92 citations,
June 2005 in “Journal of Investigative Dermatology” All-trans retinoic acid causes hair loss by increasing TGF-β2 in hair follicle cells.
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September 2004 in “Experimental Dermatology” Scalp hair follicle culture has limits for testing minoxidil's hair growth effects.
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June 2003 in “Journal of Investigative Dermatology Symposium Proceedings” TGF-β1 from dermal papilla cells suppresses hair growth, and targeting it may help treat androgenetic alopecia.
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August 1999 in “The New England Journal of Medicine” Hair follicle biology advancements may lead to better hair growth disorder treatments.
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October 2018 in “Nutrients” Annurca apple extract promotes hair growth by changing hair follicle metabolism to boost keratin production.
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March 2017 in “The journal of investigative dermatology/Journal of investigative dermatology” Growing hair follicles have high mitochondrial activity and ROS in specific regions, aiding hair formation.
130 citations,
August 2015 in “Experimental Dermatology” Human hair follicle organ culture is a useful model for hair research with potential for studying hair biology and testing treatments.
1 citations,
September 2013 in “Elsevier eBooks” Hair ages and thins due to factors like inflammation and stress, and treatments like antioxidants and hormones might improve hair health.
1 citations,
January 2022 in “Stem cell biology and regenerative medicine” New methods to test hair growth treatments have been developed.