TLDR Stat3 helps skin heal but can also cause skin diseases if overactive.
The study investigated the dual role of Stat3 in skin biology, where it supported processes like wound healing, keratinocyte migration, hair follicle growth, and UV resistance, but also contributed to skin diseases such as carcinogenesis and psoriasis when persistently activated. Experiments showed that mice lacking Stat3 did not develop skin tumors, whereas those with continuously active Stat3 developed squamous cell carcinoma more quickly. Stat3 was also found to be active in human psoriatic lesions, and its inhibition improved conditions like skin cancer and psoriasis, suggesting its potential as a therapeutic target.
17 citations
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November 2001 in “Journal of Investigative Dermatology Symposium Proceedings” 73 citations
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November 2000 in “Proceedings of the National Academy of Sciences of the United States of America” There are two ways to start hair growth: one needs Stat3 and the other does not, but both need PI3K activation.
1010 citations
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August 2000 in “Cell” Hair follicle stem cells can form both hair follicles and skin.
90 citations
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October 1996 in “Dermatologic Clinics” Growth factors are crucial for hair development and could help treat hair diseases.
114 citations
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October 1996 in “Dermatologic clinics” Hair loss is mainly caused by hormones, autoimmune issues, and chemotherapy, and needs more research for treatments.
130 citations
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January 1994 in “Differentiation” Mouse hair follicle cells briefly grow during the early hair growth phase, showing that these cells are important for starting the hair cycle.
745 citations
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February 1992 in “Trends in genetics” Hair follicles create different cell layers and proteins, controlled by various molecules.
136 citations
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May 2019 in “Cells” Stem cell therapy, particularly using certain types of cells, shows promise for treating hair loss by stimulating hair growth and development, but more extensive trials are needed to confirm these findings.
January 2025 in “Cellular & Molecular Biology Letters” Eicosanoids are crucial for skin health, and targeting their pathways may help treat skin conditions.
12 citations
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August 2022 in “Biochemical Journal” Different types of cell death affect skin health and inflammation, and understanding them could improve treatments for skin diseases.
66 citations
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March 2019 in “Cellular and Molecular Life Sciences” Melanocyte development from neural crest cells is complex and influenced by many factors, and better understanding could help treat skin disorders.
Skin stem cells are crucial for maintaining and repairing skin, with potential for treating skin disorders and improving wound healing.
