Role of STAT3 in Keratinocyte Stem Cells During Skin Tumorigenesis

January 2012 in “ DigtalCommons @ Texas Medical Center Library (Texas Medical Center) ”

Dharanija Rao

Stat3 keratinocyte stem cells KSCs skin tumorigenesis hair follicles CD34 α6 integrin progenitor populations β-catenin epidermal keratinocytes differentiation marker epithelial carcinogenesis

TLDR Stat3 affects skin cancer development by altering keratinocyte stem cell behavior.

The study investigated the role of Stat3 in keratinocyte stem cells (KSCs) during skin tumorigenesis. It was found that deleting Stat3 in the bulge region of hair follicles reduced tumor development by affecting KSC survival. In transgenic mice expressing a constitutively active form of Stat3 (Stat3C), there was a decrease in stem cell markers (CD34 and α6 integrin) and an increase in progenitor populations, suggesting that Stat3C may induce migration of KSCs by altering cell adhesion. Additionally, Stat3 deletion in the epidermis led to increased differentiation of keratinocytes. These findings indicated that Stat3 played a significant role in keratinocyte differentiation and migration, which could influence epithelial carcinogenesis.

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research Lrig1 Expression Defines a Distinct Multipotent Stem Cell Population in Mammalian Epidermis

503 citations , May 2009 in “Cell stem cell”

Lrig1 marks a unique group of stem cells in mouse skin that can become different skin cell types.

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