Apoptosis in Hair and Skin: A Review

The 2019 study reviewed the role of apoptosis (programmed cell death) in hair and skin conditions. It found that melanocyte and follicular epithelial cells are most sensitive to apoptosis, while dermal papilla cells, fibroblasts, and some keratinocytes are most resistant. The study also explored the role of apoptosis in various skin conditions such as acne vulgaris, wound healing, psoriasis, vitiligo, and skin tumors. It also discussed the role of apoptosis in diseases like sunburn, leishmaniasis, graft-versus-host disease, toxic epidermal necrolysis, erythema multiforme major, pemiphagus, systemic lupus erythematosus, dermatitis herpetiformis, eczematous dermatitis, and lichen planus. The study also focused on diabetic wounds, androgenic alopecia, skin aging, and the role of apoptosis in skin and hair cells. The review suggested that new drugs could be developed to regulate apoptosis, potentially offering new treatments for these conditions. The role of the dermal papilla cells and the HSPC016 gene in hair growth was also discussed, although the review noted that further research was needed to fully understand their roles.