TLDR Mice without the Sept4/ARTS gene heal wounds better due to more stem cells that don't die easily.
In 2013, Yaron Fuchs and colleagues conducted a study on the Sept4/ARTS gene, discovering that mice lacking this gene exhibited an increased number of hair follicle stem cells (HFSCs) that were resistant to apoptosis. This resistance led to enhanced wound healing and hair follicle regeneration. The study demonstrated that the improved healing was dependent on HFSCs and that inactivation of XIAP, a target of ARTS, could reverse these effects. Although the study involved experiments on 8-week-old mice and provided details on wound sizes, the exact number of mice used was not specified. The findings suggest that apoptosis regulation is crucial for stem cell-mediated tissue repair and that manipulating this pathway could have therapeutic potential in regenerative medicine.
265 citations,
July 2012 in “Cell” The study found that sweat glands contain different types of stem cells that help with healing and maintaining healthy skin.
254 citations,
January 2012 in “Nature Reviews Molecular Cell Biology” Stem cell offspring help control their parent stem cells, affecting tissue health, healing, and cancer.
191 citations,
September 2011 in “Cell stem cell” Hair follicle stem cells use specific chromatin changes to control their growth and differentiation.
396 citations,
May 2011 in “Cell stem cell” Nerve signals are crucial for hair follicle stem cells to become skin stem cells and help in wound healing.
829 citations,
May 2007 in “Nature” Hair follicles can regrow in wounded adult mouse skin using a process like embryo development.
788 citations,
February 2007 in “Nature” The document concludes that skin stem cells are important for hair growth and wound healing, and could be used in regenerative medicine.
25 citations,
June 2021 in “Developmental Cell” Dying cells can help with faster healing and new hair growth by releasing a growth-promoting molecule.
November 2023 in “Nature Communications” Cells lacking the Bax protein can outcompete others, leading to better tissue repair and hair growth.
April 2024 in “Cell death and differentiation” Cell death shapes skin stem cell environments, affecting inflammation, repair, and cancer.
2 citations,
August 2019 in “Journal of skin and stem cell” The study concludes that regulating apoptosis could lead to new treatments for various skin and hair conditions.
31 citations,
May 2019 in “Nature communications” Single Blimp1+ cells can create functional sebaceous gland organoids in the lab.
