Generation of the Krt24-CreERT2 Mouse Line Targeting Outer Bulge Hair Follicle Cells

    March 2025 in “ International Journal of Molecular Sciences ”
    Jiao Wang, Yifei Qiu, Yanli Zhu … Pengbo Cao
    Studysummary This study established a Krt24-CreERT2 mouse line targeting outer bulge hair follicle stem cells, finding these cells crucial for hair follicle development and repair, particularly following ionizing radiation exposure.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
    Read the full study on mdpi.com →
    Discuss this study in the Community →

    Research cited in this study 27

    1. Melatonin Promotes Hair Regeneration by Modulating the Wnt/β-Catenin Signaling Pathway Cell proliferation · 2024
    2. Recent Progress in Hair Follicle Stem Cell Markers and Their Regulatory Roles World Journal of Stem Cells · 2024
    3. Local and Systemic Mechanisms That Control the Hair Follicle Stem Cell Niche Nature Reviews Molecular Cell Biology · 2023
    4. Clinical Pathobiology of Radiotherapy-Induced Alopecia: A Guide Toward More Effective Prevention and Hair Follicle Repair ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2023
    5. EGFR Marks a Subpopulation of Dermal Mesenchymal Cells Highly Expressing IGF1 Which Enhances Hair Follicle Regeneration PubMed · 2023
    6. Corticosterone Inhibits GAS6 to Govern Hair Follicle Stem-Cell Quiescence Nature · 2021
    7. GDNF Promotes Hair Formation and Cutaneous Wound Healing by Targeting Bulge Stem Cells npj regenerative medicine · 2020
    8. A Novel Mouse Model Demonstrates That Oncogenic Melanocyte Stem Cells Engender Melanoma Resembling Human Disease Nature Communications · 2019
    9. A Subset of TREM2+ Dermal Macrophages Secretes Oncostatin M to Maintain Hair Follicle Stem Cell Quiescence and Inhibit Hair Growth Cell Stem Cell · 2019
    10. Vitamin D Receptor Is Required for Proliferation, Migration, and Differentiation of Epidermal Stem Cells and Progeny During Cutaneous Wound Repair ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2018
    11. Mobilizing Transit-Amplifying Cell-Derived Ectopic Progenitors Prevents Hair Loss from Chemotherapy or Radiation Therapy Cancer Research · 2017
    12. Hair Follicles’ Transit-Amplifying Cells Govern Concurrent Dermal Adipocyte Production Through Sonic Hedgehog Genes & Development · 2016
    13. Ceramide Synthase 4 Regulates Stem Cell Homeostasis And Hair Follicle Cycling Journal of Investigative Dermatology · 2015
    14. Emerging Interactions Between Skin Stem Cells and Their Niches Nature Medicine · 2014
    15. Cell and Tissue Damage After Skin Exposure to Ionizing Radiation: Short- and Long-Term Effects After Single and Fractional Doses Cells Tissues Organs · 2014
    16. Sept4/ARTS Regulates Stem Cell Apoptosis and Skin Regeneration Science · 2013
    17. Hairy Tale of Signaling in Hair Follicle Development and Cycling Seminars in cell & developmental biology · 2012
    18. Epithelial Wnt Ligand Secretion Is Required for Adult Hair Follicle Growth and Regeneration Journal of Investigative Dermatology · 2012
    19. A Keratin 15 Containing Stem Cell Population From the Hair Follicle Contributes to Squamous Papilloma Development in the Mouse Molecular Carcinogenesis · 2012
    20. Identification of Telogen Markers Underscores That Telogen Is Far from a Quiescent Hair Cycle Phase ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2011
    21. Nerve-Derived Sonic Hedgehog Defines a Niche for Hair Follicle Stem Cells Capable of Becoming Epidermal Stem Cells Cell stem cell · 2011
    22. Targeted Disruption of Stat3 Reveals a Major Role for Follicular Stem Cells in Skin Tumor Initiation Cancer research · 2009
    23. The Hair Follicle as a Dynamic Mini-Organ Current Biology · 2009
    24. Lgr5 Marks Cycling, Yet Long-Lived, Hair Follicle Stem Cells Nature Genetics · 2008
    25. The Human Keratins: Biology And Pathology Histochemistry and Cell Biology · 2008
    26. Keratins of the Human Hair Follicle International review of cytology · 2005
    27. Enrichment for Living Murine Keratinocytes from the Hair Follicle Bulge with the Cell Surface Marker CD34 Journal of Investigative Dermatology · 2003