Melatonin Promotes Hair Regeneration by Modulating the Wnt/β-Catenin Signaling Pathway

    May 2024 in “ Cell proliferation ”
    Yaran Niu, Y. Li, Chun‐qi Gao … Wei Ge
    Studysummary This study found that melatonin supplementation significantly promoted hair regeneration in a hair depilation mouse model by up-regulating the Wnt/β-catenin signaling pathway in dermal papillae and hair follicle stem cells, suggesting potential implications for human hair loss treatments.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
    Read the full study on onlinelibrary.wiley.com →
    Discuss this study in the Community →

    Research cited in this study 31

    1. Vitamin A Regulates Dermal Papilla Cell Proliferation and Apoptosis Under Heat Stress via IGF1 and Wnt10b Signaling Ecotoxicology and environmental safety · 2023
    2. BFNB Enhances Hair Growth in C57BL/6 Mice Through the Induction of EGF and FGF7 Factors and the PI3K-AKT-Beta-Catenin Pathway International Journal of Molecular Sciences · 2023
    3. Water Extract of Cacumen Platycladi Promotes Hair Growth Through the Akt/GSK3β/β-Catenin Signaling Pathway Frontiers in Pharmacology · 2023
    4. Hair-Growth-Promoting Effects of the Fish Collagen Peptide in Human Dermal Papilla Cells and C57BL/6 Mice Modulating Wnt/Beta-Catenin and BMP Signaling Pathways International Journal of Molecular Sciences · 2022
    5. Hedgehog Signaling Reprograms Hair Follicle Niche Fibroblasts to a Hyper-Activated State Developmental cell · 2022
    6. Exosomal miRNA-181a-5p from Hair Follicle Dermal Papilla Cells Promotes Hair Follicle Growth and Development via the Wnt/β-Catenin Signaling Pathway International journal of biological macromolecules · 2022
    7. TMT-Based Quantitative Proteomic Analysis Reveals the Effect of Bone Marrow Derived Mesenchymal Stem Cells on Hair Follicle Regeneration Frontiers in Pharmacology · 2021
    8. Liposomal Honokiol Promotes Hair Growth Via Activating Wnt3a/β-Catenin Signaling Pathway and Downregulating TGF-β1 in C57BL/6N Mice Biomedicine & Pharmacotherapy · 2021
    9. KY19382, A Novel Activator of Wnt/β-Catenin Signalling, Promotes Hair Regrowth and Hair Follicle Neogenesis British Journal of Pharmacology · 2021
    10. Dermal Exosomes Containing miR-218-5p Promote Hair Regeneration by Regulating β-Catenin Signaling Science Advances · 2020
    11. SIRT7 Activates Quiescent Hair Follicle Stem Cells to Ensure Hair Growth in Mice EMBO journal · 2020
    12. Sustained Release of Dermal Papilla-Derived Extracellular Vesicles from Injectable Microgel Promotes Hair Growth Theranostics · 2020
    13. Activating Wnt/β-Catenin Signaling Pathway for Disease Therapy: Challenges and Opportunities Pharmacology & Therapeutics · 2018
    14. Concise Review: Wnt Signaling Pathways in Skin Development and Epidermal Stem Cells Stem cells · 2017
    15. Epithelial-Mesenchymal Micro-Niches Govern Stem Cell Lineage Choices Cell · 2017
    16. Cutaneously Applied Nano-ZnO Reduces the Ability of Hair Follicle Stem Cells to Differentiate Nanotoxicology · 2017
    17. DNA Damage-Inducible Transcript 4 Is an Innate Surveillant of Hair Follicular Stress in Vitamin D Receptor Knockout Mice and a Regulator of Wound Re-Epithelialization International journal of molecular sciences · 2016
    18. Advances in Understanding Hair Growth F1000Research · 2016
    19. Resting No More: Redefining Telogen, the Maintenance Stage of the Hair Growth Cycle Biological Reviews · 2014
    20. Signaling Involved in Hair Follicle Morphogenesis and Development International Journal of Molecular Sciences · 2014
    21. Expression Of Sfrp2 Is Increased In Catagen Of Hair Follicles And Inhibits Keratinocyte Proliferation Annals of Dermatology · 2014
    22. Reprogramming Adult Dermis to a Neonatal State Through Epidermal Activation of Beta-Catenin Development · 2011
    23. The Hair Follicle as a Dynamic Mini-Organ Current Biology · 2009
    24. Melatonin and the Hair Follicle Journal of pineal research · 2007
    25. Long-Term Renewal of Hair Follicles from Clonogenic Multipotent Stem Cells Proceedings of the National Academy of Sciences of the United States of America · 2005
    26. Molecular Principles of Hair Follicle Induction and Morphogenesis BioEssays · 2005
    27. On the Role of Melatonin in Skin Physiology and Pathology Endocrine journal · 2005
    28. Transient Activation of Beta-Catenin Signaling in Adult Mouse Epidermis Induces New Hair Follicles, Continuous Activation Maintains Tumors Development · 2004
    29. Molecular Control of Epithelial-Mesenchymal Interactions During Hair Follicle Cycling ˜The œjournal of investigative dermatology. Symposium proceedings/˜The œJournal of investigative dermatology symposium proceedings · 2003
    30. Murine Skin as a Target for Melatonin Bioregulation Experimental dermatology · 1994
    31. Fiber Growth Initiation in Hair Follicles of Goats Treated with Melatonin ˜The œjournal of experimental zoology/Journal of experimental zoology · 1993