Role and Mechanisms of Phytochemicals in Hair Growth and Health

January 2023 in “ Pharmaceuticals ”

Periyanaina Kesika, Bhagavathi Sundaram Sivamaruthi, Subramanian Thangaleela, Muruganantham Bharathi, Chaiyavat Chaiyasut

From the encyclopedia

Caffeine →

the stimulant you know and love can be used topically to stimulate hair

Minoxidil →

An essential vasodilator with some anti-androgenic effects

Finasteride →

Frontline, gold standard treatment for combatting androgenic alopecia

Studysummary This review discusses factors affecting hair health, types of alopecia, and the potential of phytochemicals in managing hair loss but reports no new clinical results; it highlights the need for further studies.

Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer

The review "Role and Mechanisms of Phytochemicals in Hair Growth and Health" discusses the various factors affecting hair health and loss, including genetics, disease, lifestyle, and exposure to certain substances. It highlights the potential of phytochemicals, such as epigallocatechin gallate (EGCG), caffeine, capsaicin, and others, in developing treatments for hair problems. The paper also discusses the effectiveness of various treatments for hair loss, including minoxidil, finasteride, dutasteride, and cell therapy. It emphasizes the potential of natural products and phytochemicals in promoting hair regrowth, but concludes that further detailed studies are needed. The document also presents various studies showing the hair growth-promoting properties of different substances, including castor oil, Eclipta alba extract, and Carthamus tinctorius L. florets-loaded nanostructured lipid carrier (CTNLC). It also discusses the mechanisms through which phytochemicals promote hair growth and prevent hair loss, including interaction with the TGF-β pathway, β-catenin, JAK/STAT3 pathway, ERK signaling pathway, and 5α-reductase inhibitory property.

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In this study, smoking status and intensity were significantly associated with moderate or severe androgenetic alopecia among Asian men, after accounting for age and family history.

research Hair Loss in Children in South-East Nigeria: Common and Uncommon Cases

34 citations , October 2007 in “International Journal of Dermatology”

This study reported that the most common hair loss disorder among children in south-east Nigeria was tinea capitis, and its clinical course was influenced by parental attitudes towards treatment.

A Multicenter, Randomized, Placebo-Controlled, Double-Blind Clinical Trial of a Novel Formulation of 5% Minoxidil Topical Foam Versus Placebo in the Treatment of Androgenetic Alopecia in Men

research A Multicenter, Randomized, Placebo-Controlled, Double-Blind Clinical Trial of a Novel Formulation of 5% Minoxidil Topical Foam Versus Placebo in the Treatment of Androgenetic Alopecia in Men

142 citations , August 2007 in “Journal of The American Academy of Dermatology”

This study found that a new 5% minoxidil foam formulation significantly increased hair counts and improved hair loss condition in men with androgenetic alopecia over 16 weeks compared to placebo.

research A New Classification of Pattern Hair Loss That Is Universal for Men and Women: Basic and Specific (BASP) Classification

125 citations , May 2007 in “Journal of The American Academy of Dermatology”

This study describes the development of the BASP classification system, providing a universal and systematic approach for classifying pattern hair loss in both men and women.

research Effect of Caffeine and Testosterone on the Proliferation of Human Hair Follicles In Vitro

114 citations , January 2007 in “International Journal of Dermatology”

This study found that caffeine can stimulate hair growth in vitro and counteract testosterone-induced growth suppression in hair follicles from male AGA patients.

research Effect of Finasteride 5 mg (Proscar) on Acne and Alopecia in Female Patients with Normal Serum Levels of Free Testosterone

43 citations , January 2007 in “Gynecological Endocrinology”

This study found that 9 out of 12 women with acne or alopecia showed subjective improvement with finasteride treatment despite having normal free testosterone levels, suggesting a potential role of 5alpha-reductase activity.

The Importance of Dual 5α-Reductase Inhibition in the Treatment of Male Pattern Hair Loss: Results of a Randomized Placebo-Controlled Study of Dutasteride Versus Finasteride

research The Importance of Dual 5α-Reductase Inhibition in the Treatment of Male Pattern Hair Loss: Results of a Randomized Placebo-Controlled Study of Dutasteride Versus Finasteride

215 citations , November 2006 in “Journal of The American Academy of Dermatology”

This study found that dutasteride increased scalp hair growth in men with male pattern hair loss, particularly at a 2.5 mg dose, and was more effective than finasteride over 24 weeks.

research Effects of Finasteride (1 mg) on Hair Transplant

30 citations , March 2006 in “Dermatologic Surgery”

In this study of men with androgenetic alopecia, daily finasteride 1 mg alongside hair transplant improved scalp hair density and growth of nontransplanted hair compared to placebo over 48 weeks.

research Finasteride Treatment of Female Pattern Hair Loss

108 citations , March 2006 in “Archives of Dermatology”

This study observed that 62% of premenopausal women with female pattern hair loss reported improvement when treated with oral finasteride and an oral contraceptive containing drospirenone and ethinyl estradiol.

research Effects of Finasteride (1 mg) on Hair Transplant

23 citations , October 2005 in “Dermatologic Surgery”

This study found that finasteride 1 mg daily, taken before and after hair transplant surgery, significantly improved scalp hair coverage and density in men with androgenetic alopecia compared to placebo.

research Aging of Hair

99 citations , June 2005 in “Journal of Cosmetic Dermatology”

This article reviews factors influencing hair aging and available treatments like minoxidil and finasteride for androgenetic alopecia but reports no new clinical results.

research Minoxidil: Mechanisms of Action on Hair Growth

397 citations , February 2004 in “British Journal of Dermatology”

This article reviews the mechanisms by which minoxidil stimulates hair growth and reports no new clinical findings.

research Family History and Risk of Hair Loss

49 citations , January 2004 in “Dermatology”

This study found that men with a paternal history of hair loss were significantly more likely to experience hair loss themselves.

research An Open, Randomized, Comparative Study of Oral Finasteride and 5% Topical Minoxidil in Male Androgenetic Alopecia

71 citations , January 2004 in “Dermatology”

This study found that oral finasteride was more effective than 5% topical minoxidil in treating mild to severe androgenetic alopecia in males, with both treatments deemed effective and safe over 12 months.

research Female Pattern Hair Loss

30 citations , October 2002 in “Journal of The American Academy of Dermatology”

Use "female pattern hair loss" term, finasteride may help, more research needed.

research Telogen Effluvium: Causes, Diagnosis, and Treatment

144 citations , July 2002 in “Clinical and Experimental Dermatology”

This article reviews the concept of telogen effluvium and emphasizes the importance of identifying triggers and using diagnostic investigations to determine the cause of hair loss, without reporting new results.

research Onion Juice (Allium Cepa L.), A New Topical Treatment For Alopecia Areata

95 citations , June 2002 in “The Journal of Dermatology”

In this study, using topical crude onion juice significantly improved hair regrowth in patients with patchy alopecia areata compared to tap water.

research Effects of Minoxidil 2% vs. Cyproterone Acetate Treatment on Female Androgenetic Alopecia: A Controlled, 12-Month Randomized Trial

149 citations , June 2002 in “British Journal of Dermatology”

Minoxidil works better for female hair loss, but cyproterone reduces scalp oiliness and causes menstrual issues.

A Randomized, Double-Blind, Placebo-Controlled Trial to Determine the Effectiveness of Botanically Derived Inhibitors of 5-Alpha-Reductase in the Treatment of Androgenetic Alopecia

research A Randomized, Double-Blind, Placebo-Controlled Trial to Determine the Effectiveness of Botanically Derived Inhibitors of 5-Alpha-Reductase in the Treatment of Androgenetic Alopecia

68 citations , April 2002 in “Journal of Alternative and Complementary Medicine”

This study suggests that botanical 5AR inhibitors like Serenoa repens and β-sitosterol may improve symptoms of androgenetic alopecia, with 60% of treated subjects showing improvement compared to placebo.

research A Randomized, Double-Blind, Placebo-Controlled Trial to Determine the Effectiveness of Botanically Derived Inhibitors of 5-Alpha-Reductase in the Treatment of Androgenetic Alopecia

65 citations , April 2002 in “Journal of Alternative and Complementary Medicine”

This study found that 60% of men with mild to moderate androgenetic alopecia showed improvement after treatment with botanically derived 5AR inhibitors, suggesting these compounds may be effective, though larger trials are needed.

research Female Pattern Hair Loss

226 citations , September 2001 in “Journal of The American Academy of Dermatology”

Hair loss in women is genetic, diagnosed by examination and biopsy, and treated with minoxidil, finasteride, or transplantation.

research The First Clinical Trial of Topical Application of Procyanidin B-2 to Investigate Its Potential as a Hair Growing Agent

26 citations , June 2001 in “PTR. Phytotherapy research/Phytotherapy research”

This study reported that a 1% procyanidin B-2 tonic increased hair diameter and density in men with male pattern baldness, suggesting it may be a potential treatment option.

research Hair Loss in Psychopharmacology

63 citations , March 2000 in “Annals of clinical psychiatry”

This article reviews the association between psychopharmaceuticals and medication-induced alopecia, noting that hair regrowth typically occurs after discontinuing or reducing the medication, while mineral supplements' effectiveness remains unclear.

research Hair Loss in Psychopharmacology

79 citations , January 2000 in “Annals of Clinical Psychiatry”

This review discusses the potential for mood stabilizers, antidepressants, and some antipsychotic and antianxiety drugs to induce alopecia and reports no clinical results.

research Telogen Effluvium: New Concepts and Review

69 citations , March 1993 in “Archives of Dermatology”

This article proposes five mechanisms for telogen effluvium based on changes in the follicular cycle, which are supported by clinical findings, highlighting the condition's diverse causes.

research Telogen Effluvium: A Comprehensive Review

214 citations , March 1993 in “Archives of Dermatology”

This article proposes five different mechanisms for telogen effluvium, supported by clinical findings, based on changes in different phases of the hair cycle.

Hair Growth Effects of Oral Administration of Finasteride, a Steroid 5 Alpha-Reductase Inhibitor, Alone and in Combination with Topical Minoxidil in the Balding Stumptail Macaque

research Hair Growth Effects of Oral Administration of Finasteride, a Steroid 5 Alpha-Reductase Inhibitor, Alone and in Combination with Topical Minoxidil in the Balding Stumptail Macaque

34 citations , February 1992 in “The Journal of Clinical Endocrinology and Metabolism”

In this study, the combination of finasteride and minoxidil significantly increased hair growth in balding male stumptail macaques compared to each drug alone.