Anti-Inflammatory, Thrombolytic, and Hair-Growth Promoting Activity of the n-Hexane Fraction of the Methanol Extract of Leea Indica Leaves

    May 2021 in “ Plants ”
    Shahenur Alam Sakib, Abu Montakim Tareq, Ameerul Islam, Ahmed Rakib, Mohammad Nazmul Islam, Mohammad Arafat Uddin, Md. Masudur Rahman, Véronique Seidel, Talha Bin Emran
    Image of study
    TLDR The leaf extract of Leea indica may reduce inflammation, dissolve blood clots, and promote hair growth.
    The study explored the effects of the n-hexane fraction from the methanol extract of Leea indica (NFLI) leaves on inflammation, blood clot dissolution, and hair growth. NFLI showed significant anti-inflammatory properties by inhibiting hemolysis and protein denaturation. It also displayed thrombolytic activity in a concentration-dependent manner. When applied topically to mice, NFLI at 1% concentration notably increased hair length, with the highest hair regrowth percentages observed on days 7, 14, and 21 (81.24%, 65.60%, and 62.5%, respectively). Additionally, an in silico study indicated that certain phytochemicals in NFLI could bind to PGD2 synthase, an enzyme implicated in hair loss, suggesting that L. indica may be an effective natural treatment for alopecia. However, further research is needed to confirm its efficacy and safety.
    Discuss this study in the Community →

    Research cited in this study

    17 / 17 results

    Related Community Posts Join

    6 / 372 results

      community Before n after… #OralMinfortheWin

      in Progress Pictures  71 upvotes 1 year ago
      The user "mallanboy" shared their experience with using 0.5mg Dutasteride once a week, 0.5mg Finasteride every day, and 2.5mg Minoxidil every day for hair loss. They mentioned that their hairline has slightly improved and their hair density has increased after switching from topical minoxidil to oral minoxidil after 8 months. They hope to maintain their results until they are 30 years old for a hair transplant.

      community Nanoxidil Spectral.DNC-n 60ml.

      in Treatment  1 upvotes 10 months ago
      A user recently started using nanoxidil 5% for hair loss, particularly on the hairline, and is seeking feedback or experiences from others. The conversation focuses on the effectiveness of nanoxidil.

      community Started to See Progress but Greying Out

      in Treatment  2 upvotes 1 year ago
      The user has been using a hair loss treatment regimen including Minokem N, topical finasteride+minoxidil, and oral minoxidil for three months and has seen progress. However, they've also noticed an increase in grey hair, particularly on the sides of their head, and are seeking advice.

      community Sharing what worked for me (PCOS related hair loss)

      in Female  32 upvotes 10 months ago
      A user with PCOS experienced hair loss and found success using a triple dose of O.N.E Omega by Pure Encapsulations after discovering low Omega fatty acids. Biotin provided minimal improvement, but the Omega supplement significantly restored hair.

      community Are carbohydrates needed for hair growth

      in Research/Science  26 upvotes 3 months ago
      A 47-year-old male experienced significant hair loss after losing 37 kg in 6 months on a low-carb diet and started taking biotin, zinc, iron, selenium, and spectral dcn-n. Replies suggest that while carbs are not directly needed for hair growth, they help regulate hormones and nutrient absorption, and rapid weight loss can also contribute to hair loss.

      community anything to add to my regime?

      in Advice 4 years ago
      The conversation is about a hair loss treatment regimen that includes finasteride, dutasteride, oral minoxidil, Dermapen, quercetin, N-acetyl L-cysteine, biotin, millet seed extract, MSM, OPC, green tea extract, high-dose vitamins B1-B12, boron, and silica. The user is seeking advice on additional treatments.

    Similar Research

    5 / 1000+ results