Chemical Profiling, Pharmacological Insights, and In Silico Studies of Methanol Seed Extract of Sterculia Foetida

The study on the methanol seed extract of Sterculia foetida (MESF) revealed its potential as a source of therapeutic agents due to its significant pharmacological activities, including thrombolytic, anti-arthritic, analgesic, and antipyretic effects. The extract contained 29 compounds, primarily phenols, terpenoids, and esters, and demonstrated moderate cytotoxicity in brine shrimp lethality assays. Molecular docking studies identified 1-azuleneethanol, acetate as a promising compound with high binding affinity to receptors involved in these activities, suggesting strong anti-inflammatory and analgesic potentials. The study also evaluated the ADME characteristics and toxicological properties of the compounds, indicating potential clinical applications but recommending further analysis to isolate and identify the bioactive components responsible for the pharmacological effects.