Hair Growth Promoting Effect of Dicerocaryum Senecioides Phytochemicals

The study from 2019 found that flavonoid glycosides extracted from the plant Dicerocaryum senecioides significantly promoted hair growth in BalB/c mice. The treated mice exhibited the shortest hair growth completion time of 19 days, the longest hair length (11.04 mm for males and 11.86 mm for females), and the heaviest hair weight (56.61 ± 1.30 mg for males and 54.44 ± 2.52 mg for females) after 21 days of treatment, outperforming the control group and the standard hair growth drug, 2% minoxidil. The hair growth effects were dose-dependent and the extract was found to be safe for topical application with no observed toxicity at a concentration of 200 mg/mL. The study suggests that these phytochemicals could be potential treatments for nonhormonal forms of alopecia and warrant further research to understand their effects on androgenic alopecia and the underlying mechanisms of action.