A Randomized, Double-Blind, Placebo-Controlled Trial to Determine the Effectiveness of Botanically Derived Inhibitors of 5-Alpha-Reductase in the Treatment of Androgenetic Alopecia

    Nelson Prager, Karen Bickett, Nita French, Geno Marcovici
    Studysummary This study suggests that botanical 5AR inhibitors like Serenoa repens and β-sitosterol may improve symptoms of androgenetic alopecia, with 60% of treated subjects showing improvement compared to placebo.
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    Research cited in this study 4

    1. Finasteride, 1 mg (Propecia), Is the Optimal Dose for the Treatment of Men With Male Pattern Hair Loss Archives of Dermatology · 1999
    2. Mechanism of Action of Androgen in Hair Follicles Journal of dermatological science · 1994
    3. C19 and C21 5β/5α Metabolite Ratios in Subjects Treated with the 5α-Reductase Inhibitor Finasteride: Comparison of Male Pseudohermaphrodites with Inherited 5α-Reductase Deficiency The Journal of Clinical Endocrinology and Metabolism · 1990
    4. Quantitative Assessment of 2% Topical Minoxidil in the Treatment of Male Pattern Baldness Clinical and Experimental Dermatology · 1989