Therapeutic Potential of Gynostemma Pentaphyllum Extract for Hair Health Enhancement: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial

    February 2025 in “ Nutrients ”
    Ji‐Hyun Lee, Yongxun Jin, Xinrui Zhang … Chan Yeong Heo
    Studysummary This randomized controlled trial found that consuming *Gynostemma pentaphyllum* extract significantly improved hair elasticity, density, and diameter over 24 weeks without severe adverse events, suggesting it as a safe functional food ingredient for hair health improvement.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
    Read the full study on mdpi.com →
    Discuss this study in the Community →

    Research cited in this study 17

    1. Efficacy and Safety of Deuruxolitinib, an Oral Selective Janus Kinase Inhibitor, in Adults with Alopecia Areata: Results from the Phase 3 Randomized, Controlled Trial (THRIVE-AA1) Journal of the American Academy of Dermatology · 2024
    2. Can Plant Extracts Help Prevent Hair Loss or Promote Hair Growth? A Review Comparing Their Therapeutic Efficacies, Phytochemical Components, and Modulatory Targets Molecules/Molecules online/Molecules annual · 2024
    3. Gynostemma Pentaphyllum Hydrodistillate and Its Major Component Damulin B Promote Hair Growth via the Wnt/Beta-Catenin Pathway Nutrients · 2024
    4. Effectiveness and Safety of Hair Growth Formulation Containing Tectona Grandis L.f (Teak) Leaf Extract: A Randomized, Double-Blind, Placebo-Controlled Study on Males with Androgenic Alopecia Journal of Evidence-Based Integrative Medicine · 2024
    5. Oral and Topical Administration of Standardized Saw Palmetto Oil Reduces Hair Fall and Improves Hair Growth in Androgenetic Alopecia Subjects: A 16-Week Randomized, Placebo-Controlled Study Clinical, Cosmetic and Investigational Dermatology · 2023
    6. Gynostemma Pentaphyllum Makino Extract Induces Hair Growth And Exhibits An Anti-Graying Effect Via Multiple Mechanisms Journal of Cosmetic Dermatology · 2023
    7. Efficacy and Safety of Persimmon Leaf Formulated With Green Tea and Sophora Fruit Extracts on Hair Growth: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial Skin Research and Technology · 2023
    8. Medical and Procedural Treatment of Androgenetic Alopecia – Where Are We? Journal of The American Academy of Dermatology · 2023
    9. The Effect of an Oral Product Containing Amla Fruit on Female Androgenetic Alopecia: A Randomized Controlled Trial Journal of Ethnopharmacology · 2023
    10. Evaluation of Platelet-Rich Plasma Plus Basic Fibroblast Growth Factor Combined With Minoxidil in the Treatment of Androgenetic Alopecia: A Randomized Controlled Trial Journal of Cosmetic Dermatology · 2023
    11. Role and Mechanisms of Phytochemicals in Hair Growth and Health Pharmaceuticals · 2023
    12. Evaluation of the Safety and Effectiveness of Nutritional Supplements for Treating Hair Loss JAMA dermatology · 2022
    13. Treatment Options for Androgenetic Alopecia: Efficacy, Side Effects, Compliance, Financial Considerations, and Ethics Journal of Cosmetic Dermatology · 2021
    14. Comment on 'Low Dose Oral Minoxidil for Treating Alopecia: A 3-Year North American Retrospective Case Series': Adding Further Evidence About Side Effects Journal of The American Academy of Dermatology · 2021
    15. Autologous Cell-Based Therapy for Male and Female Pattern Hair Loss Using Dermal Sheath Cup Cells: A Randomized Placebo-Controlled Double-Blinded Dose-Finding Clinical Study Journal of The American Academy of Dermatology · 2020
    16. The Impact of Oxidative Stress on Hair International Journal of Cosmetic Science · 2015
    17. Effect of Pumpkin Seed Oil on Hair Growth in Men with Androgenetic Alopecia: A Randomized, Double-Blind, Placebo-Controlled Trial Evidence-based Complementary and Alternative Medicine · 2014