Can Plant Extracts Help Prevent Hair Loss or Promote Hair Growth? A Review Comparing Their Therapeutic Efficacies, Phytochemical Components, and Modulatory Targets

    May 2024 in “ Molecules/Molecules online/Molecules annual ”
    Joon Yong Choi, Min Young Boo, Yong Chool Boo
    Studysummary This narrative review reports that well-selected plant extracts and their active compounds may improve hair health by promoting hair growth and preventing hair loss, potentially aiding in developing targeted therapies for alopecia.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
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    Research cited in this study 118

    1. Ginsenosides in Panax Ginseng Extract Promote Anagen Transition by Suppressing BMP4 Expression and Promote Human Hair Growth by Stimulating Follicle-Cell Proliferation Biological & pharmaceutical bulletin · 2024
    2. Assessing the Impact of Alopecia on Quality of Life, Depression, and Self-Esteem in Saudi Arabia Curēus · 2023
    3. Hair Growth Promotion and Anti-Hair Loss Effects of Arabica Coffee Pulp Extracts Using Supercritical Fluid Extraction Foods · 2023
    4. Local and Systemic Mechanisms That Control the Hair Follicle Stem Cell Niche Nature Reviews Molecular Cell Biology · 2023
    5. Evaluation of Efficacy of Silybum Marianum Flower Extract on Mitigating Hair Loss In Vitro and In Vivo Journal of cosmetic dermatology · 2023
    6. Gynostemma Pentaphyllum Makino Extract Induces Hair Growth And Exhibits An Anti-Graying Effect Via Multiple Mechanisms Journal of Cosmetic Dermatology · 2023
    7. Efficacy and Safety of Persimmon Leaf Formulated With Green Tea and Sophora Fruit Extracts on Hair Growth: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial Skin Research and Technology · 2023
    8. Hair Growth-Promoting Activity of Hair Tonic Containing Delipidated Ethanol Extract of Capsicum Frutescens L. Leaves on Male Rabbit Research journal of pharmacy and technology · 2023
    9. The In Vivo and In Vitro Effects of Terminalia Bellirica Fruit Extract on Testosterone-Induced Hair Loss Journal of Microbiology and Biotechnology · 2023
    10. Potential Natural Products Regulation of Molecular Signaling Pathway in Dermal Papilla Stem Cells Molecules · 2023
    11. Use of 5-Alpha Reductase Inhibitors in Dermatology: A Narrative Review Dermatology and Therapy · 2023
    12. Protective Activity Against Oxidative Stress in Dermal Papillae With Extracted Herbal Essential Oils Applied sciences · 2023
    13. 5-Alpha Reductase Inhibitors Use in Prostatic Disease and Beyond Translational Andrology and Urology · 2023
    14. Effects of Cudrania Tricuspidata and Sargassum Fusiforme Extracts on Hair Growth in C57BL/6 Mice Laboratory Animal Research · 2023
    15. Examining the Effect of Notocactus Ottonis Cold Vacuum Isolated Plant Cell Extract on Hair Growth in C57BL/6 Mice Molecules · 2023
    16. Role and Mechanisms of Phytochemicals in Hair Growth and Health Pharmaceuticals · 2023
    17. Integrative and Mechanistic Approach to the Hair Growth Cycle and Hair Loss Journal of Clinical Medicine · 2023
    18. Effects of Hormones and Endocrine Disorders on Hair Growth Cureus · 2022
    19. Lactobacillus Paracasei HY7015 and Lycopus Lucidus Turcz. Extract Promotes Human Dermal Papilla Cell Cytoprotective Effect and Hair Regrowth Rate in C57BL/6 Mice Molecules/Molecules online/Molecules annual · 2022
    20. Assessment of the Anti-Hair Loss Potential of Camellia Japonica Fruit Shell Extract In Vitro International Journal of Cosmetic Science · 2022
    21. Hair Growth Test in Male Rabbits with Variations in the Concentration of Ethanol Extract from Terentang Stem Barks Journal of Advances in Pharmacy Practices · 2022
    22. Regenerative Medicine Strategies for Hair Growth and Regeneration: A Narrative Review of Literature Regenerative Therapy · 2022
    23. An Overview of the Genetic Aspects of Hair Loss and Its Connection with Nutrition PubMed · 2022
    24. Camellia Seed Cake Extract Supports Hair Growth by Abrogating the Effect of Dihydrotestosterone in Cultured Human Dermal Papilla Cells Molecules · 2022
    25. Comprehensive Review of Oral Minoxidil in Alopecia Journal of Cosmetic Dermatology · 2022
    26. In Vitro Hair Growth and Hair Tanning Activities of Mangosteen Pericarp Extract on Hair Dermal Papilla Cells Journal of Herbal Medicine · 2022
    27. Phytochemical Constitution, Anti-Inflammation, Anti-Androgen, and Hair Growth-Promoting Potential of Shallot (Allium Ascalonicum L.) Extract Plants · 2022
    28. Morphogenesis, Growth Cycle, and Molecular Regulation of Hair Follicles Frontiers in Cell and Developmental Biology · 2022
    29. Hair Growth-Promoting Effects of Camellia Seed Cake Extract in Human Dermal Papilla Cells and C57BL/6 Mice Journal of Cosmetic Dermatology · 2022
    30. The Effects of Centipedegrass Extract on Hair Growth via Promotion of Anagen Inductive Activity PLoS ONE · 2022
    31. Formulation of Hair Tonic from Ethanol Extract of Sea Hibiscus (Hibiscus Tiliaceus L.) Leaves in Promoting Hair Growth on Guinea Pigs (Cavia Porcellus) Journal of drug delivery and therapeutics · 2022
    32. Isolation and Identification of Hair Growth Potential Fraction from Active Plant Extract of Blumea Eriantha DC Grown in Western Ghat of India: In Silico Study Journal of Ayurveda and integrative medicine · 2022
    33. Effects of Watercress Extract Fraction on R-Spondin 1-Mediated Growth of Human Hair International Journal of Cosmetic Science · 2022
    34. Pinus Thunbergii Bark Extract Rich in Flavonoids Promotes Hair Growth in Dorsal Skin by Regulating Inflammatory Cytokines and Increasing Growth Factors in Mice Molecular Medicine Reports · 2022
    35. Wnt/β-Catenin Signaling: Function, Biological Mechanisms, and Therapeutic Opportunities Signal Transduction and Targeted Therapy · 2022
    36. Growth Hormone and the Human Hair Follicle International journal of molecular sciences · 2021
    37. Formulation and Evaluation of Phytosome Lotion from Nothopanax Scutellarium Leaf Extract for Hair Growth International Journal of Applied Pharmaceutics · 2021
    38. Perspectives on MicroRNAs Targeting DKK1 for Developing Hair Regeneration Therapy Cells · 2021
    39. Hair Growth-Promotion Effects at the Cellular Level and Antioxidant Activity of the Plant-Based Extract Phyllotex Heliyon · 2021
    40. Hair Growth Stimulation Effect of Centipeda Minima Extract: Identification of Active Compounds and Anagen-Activating Signaling Pathways Biomolecules · 2021
    41. Minoxidil: A Comprehensive Review Journal of Dermatological Treatment · 2021
    42. Anti-Inflammatory, Thrombolytic, and Hair-Growth Promoting Activity of the n-Hexane Fraction of the Methanol Extract of Leea Indica Leaves Plants · 2021
    43. Effects of UV-Induced Photoaging on the Hair Follicle Cycle of C57BL6/J Mice Clinical, cosmetic and investigational dermatology · 2021
    44. Topical Treatment for Scarring and Non-Scarring Alopecia: An Overview of the Current Evidence Clinical, Cosmetic and Investigational Dermatology · 2021
    45. Brassica Oleracea Extract, Glucosinolates, And Sulforaphane Promote Hair Growth In Vitro And Ex Vivo Journal of Cosmetic Dermatology · 2021
    46. Screening of Hair Growth Promoting Activity of Punica Granatum L. (Pomegranate) Leaves Extracts and Its Potential to Exhibit Antidandruff and Anti-Lice Effect Heliyon · 2021
    47. Hair Growth Promotion Effect of Nelumbinis Semen Extract with High Antioxidant Activity Evidence-based Complementary and Alternative Medicine · 2021
    48. Functional Hair Follicle Regeneration: An Updated Review Signal Transduction and Targeted Therapy · 2021
    49. Immunology of Alopecia Areata Central-European Journal of Immunology/Central European Journal of Immunology · 2020
    50. In Vivo and In Vitro Hair Growth-Promoting Effect of Silver and Iron Nanoparticles Synthesized via Blumea Eriantha DC Plant Extract Journal of Cosmetic Dermatology · 2020
    51. Effects of Decursin and Angelica Gigas Nakai Root Extract on Hair Growth in Mouse Dorsal Skin via Regulating Inflammatory Cytokines Molecules · 2020
    52. Hormonal Effects on Hair Follicles International journal of molecular sciences · 2020
    53. Development of Ethosome Comprising Combined Herbal Extracts and Its Effect on Hair Growth Advances in Traditional Medicine · 2020
    54. Hair Growth Effect of Emulsion Extracted Brevilin A, a JAK3 Inhibitor, from Centipeda Minima Processes · 2020
    55. Hormonal Regulation in Male Androgenetic Alopecia: Sex Hormones and Beyond - Evidence from Recent Genetic Studies Experimental Dermatology · 2020
    56. Polygonum Multiflorum Extract Supports Hair Growth by Elongating Anagen Phase and Abrogating the Effect of Androgen in Cultured Human Dermal Papilla Cells BMC complementary medicine and therapies · 2020
    57. Extract of Plumbago Zeylanica Enhances the Growth of Hair Follicle Dermal Papilla Cells with Down-Regulation of 5α-Reductase Type II Journal of Cosmetic Dermatology · 2020
    58. The Potency of Hibiscus Rosa-Sinensis Linn. Leaves Ethanol Extract as Hair Growth Open Access Macedonian Journal of Medical Sciences · 2020
    59. Hair Growth Potential of Salvia Plebeia Extract and Its Associated Mechanisms Pharmaceutical Biology · 2020
    60. Alcohol Extract from Vernonia Anthelmintica Seed Counteracts Stress-Induced Murine Hair Follicle Growth Inhibition BMC Complementary and Alternative Medicine · 2019
    61. Hair Growth Promotion by Extracts of Inula Helenium and Caesalpinia Sappan Bark in Patients with Androgenetic Alopecia: A Pre-Clinical Study Using Phototrichogram Analysis Cosmetics · 2019
    62. Poly(γ-Glutamic Acid)/Chitosan Hydrogel Nanoparticles for Effective Preservation and Delivery of Fermented Herbal Extract for Enlarging Hair Bulb and Enhancing Hair Growth International Journal of Nanomedicine · 2019
    63. Hair Growth Promoting Effect of Houttuynia Cordata Extract in Cultured Human Hair Follicle Dermal Papilla Cells Biological & Pharmaceutical Bulletin · 2019
    64. Novel Shampoo Reduces Hair Shedding by Contracting the Arrector Pili Muscle via the Trace Amine-Associated Receptor Journal of Cosmetic Dermatology · 2019
    65. Can Plant-Derived Phytochemicals Provide Symptom Relief for Hair Loss? A Critical Review International Journal of Cosmetic Science · 2019
    66. Blackcurrant Extract with Phytoestrogen Activity Alleviates Hair Loss in Ovariectomized Rats Molecules · 2019
    67. The Balance of BMP6 and WNT10B Regulates the Telogen-Anagen Transition of Hair Follicles Cell Communication and Signaling · 2019
    68. The Efficacy and Safety of Dutasteride Compared with Finasteride in Treating Men with Androgenetic Alopecia: A Systematic Review and Meta-Analysis Clinical Interventions in Aging · 2019
    69. RE-ORGA, a Korean Herb Extract, Can Prevent Hair Loss Induced by Dihydrotestosterone in Human Dermal Papilla Cells Annals of Dermatology · 2019
    70. Effect of Cinnamomum Osmophloeum Kanehira Leaf Aqueous Extract on Dermal Papilla Cell Proliferation and Hair Growth Cell transplantation · 2018
    71. Scalp Condition Impacts Hair Growth And Retention Via Oxidative Stress International journal of trichology · 2018
    72. Sesquiterpene-Enriched Extract of Curcuma Aeruginosa Roxb. Retards Axillary Hair Growth: A Randomized, Placebo-Controlled, Double-Blind Study Skin Pharmacology and Physiology · 2018
    73. A Proprietary Herbal Extract Against Hair Loss in Androgenetic Alopecia and Telogen Effluvium: A Placebo-Controlled, Single-Blind, Clinical-Instrumental Study Acta dermatovenerologica Alpina, Pannonica et Adriatica (Tiskana izd.) · 2018
    74. The Promotion of Hair Regrowth by Topical Application of a Perilla Frutescens Extract Through Increased Cell Viability and Antagonism of Testosterone and Dihydrotestosterone Journal of Natural Medicines · 2017
    75. Further Clinical Evidence for the Effect of IGF-1 on Hair Growth and Alopecia Skin appendage disorders · 2017
    76. Evaluation of the Effect of Plant Mixture Ethanol Extracts Containing Biota Orientalis L. Extract on Suppression of Sebum in Cultured Sebocytes and on Stimulation of Growth of Keratinocytes Co-cultured with Hair Papilla Cells Cosmetics · 2017
    77. Impact of Trigonella Foenum-Graecum Leaves Extract on Mice Hair Growth Pakistan Journal of Zoology · 2017
    78. Hair Growth-Promoting Effect of Geranium Sibiricum Extract in Human Dermal Papilla Cells and C57BL/6 Mice BMC Complementary and Alternative Medicine · 2017
    79. Effect of Orthosiphon Stamineus Plant Extract on In Vitro Dermal Papilla Cell Proliferation and Ex Vivo Hair Growth Deleted Journal · 2017
    80. Preclinical and Clinical Studies Demonstrate That the Proprietary Herbal Extract DA-5512 Effectively Stimulates Hair Growth and Promotes Hair Health Evidence-based Complementary and Alternative Medicine · 2017
    81. Hot Water Extract of Oriental Melon Leaf Promotes Hair Growth and Prolongs Anagen Hair Cycle: In Vivo and In Vitro Evaluation Food Science and Biotechnology · 2016
    82. The Hair Growth-Promoting Effect of Rumex Japonicus Houtt. Extract Evidence-based Complementary and Alternative Medicine · 2016
    83. Classifications of Patterned Hair Loss: A Review Journal of Cutaneous and Aesthetic Surgery · 2016
    84. The Impact of Oxidative Stress on Hair International Journal of Cosmetic Science · 2015
    85. Action Mechanism of Natural Plant Extracts for Hair Loss Prevention and Hair Growth Promotion in C57BL/6 Mice International journal of pharmacology · 2015
    86. In Vivo Hair Growth-Stimulating Effect of Medicinal Plant Extract on BALB/c Nude Mice Pharmaceutical Biology · 2015
    87. Safety and Efficacy of Rice Bran Supercritical CO2 Extract for Hair Growth in Androgenic Alopecia: A 16-Week Double-Blind Randomized Controlled Trial Biological & Pharmaceutical Bulletin · 2015
    88. Red Ginseng Extract Promotes Hair Growth in Cultured Human Hair Follicles Journal of Medicinal Food · 2014
    89. The Structure of People's Hair PeerJ · 2014
    90. Platycarya Strobilacea S. Et Z. Extract Has a High Antioxidant Capacity and Exhibits Hair Growth-Promoting Effects in Male C57BL/6 Mice Journal of Food Science and Nutrition · 2014
    91. The Dermal Papilla: An Instructive Niche for Epithelial Stem and Progenitor Cells in Development and Regeneration of the Hair Follicle Cold Spring Harbor Perspectives in Medicine · 2014
    92. Chrysanthemum Zawadskii Extract Induces Hair Growth by Stimulating the Proliferation and Differentiation of Hair Matrix International Journal of Molecular Medicine · 2014
    93. Effects of Lycopersicon Esculentum Extract on Hair Growth and Alopecia Prevention PubMed · 2014
    94. Signaling Involved in Hair Follicle Morphogenesis and Development International Journal of Molecular Sciences · 2014
    95. In Vivo Hair Growth-Promoting Effect of Rice Bran Extract Prepared by Supercritical Carbon Dioxide Fluid Biological & Pharmaceutical Bulletin · 2013
    96. The Human Hair: From Anatomy to Physiology International Journal of Dermatology · 2013
    97. Hair Growth-Promoting Effect of Carthamus Tinctorius Floret Extract Phytotherapy Research · 2013
    98. Induction of Transforming Growth Factor-Beta 1 by Androgen Is Mediated by Reactive Oxygen Species in Hair Follicle Dermal Papilla Cells Journal of Biochemistry and Molecular Biology · 2013
    99. A Hair Growth-Promoting Effect of Chinese Black Tea Extract in Mice Bioscience, Biotechnology, and Biochemistry · 2013
    100. Hair Growth-Promoting Activity of Hot Water Extract of Thuja Orientalis BMC Complementary and Alternative Medicine · 2013
    101. Hair Growth-Promoting Effect of Aconiti Ciliare Tuber Extract Mediated by the Activation of Wnt/β-Catenin Signaling Life Sciences · 2012
    102. VEGF Induces Proliferation of Human Hair Follicle Dermal Papilla Cells Through VEGFR-2-Mediated Activation of ERK Experimental Cell Research · 2012
    103. Promotion of Hair Growth by Rosmarinus Officinalis Leaf Extract Phytotherapy Research · 2012
    104. Potentiality of Aqueous Leaf Extract of Trichosanthes Cucumerina Linn. on Hair Growth Promotion in Wistar Albino Rats 2012
    105. Effects of a New Mild Shampoo for Preventing Hair Loss in Asians Using a Simple Hand-Held Phototrichogram Technique International Journal of Cosmetic Science · 2011
    106. Topical Application of Polygonum Multiflorum Extract Induces Hair Growth of Resting Hair Follicles Through Upregulating Shh and β-Catenin Expression in C57BL/6 Mice Journal of Ethnopharmacology · 2011
    107. Eclipta Alba Extract With Potential For Hair Growth Promoting Activity Journal of Ethnopharmacology · 2009
    108. KGF And EGF Signaling Block Hair Follicle Induction And Promote Interfollicular Epidermal Fate In Developing Mouse Skin Development · 2009
    109. Hair Growth Regulation by the Extract of Aromatic Plant Erica Multiflora Journal of Natural Medicines · 2009
    110. The Hair Follicle as a Dynamic Mini-Organ Current Biology · 2009
    111. Double-Blind, Randomized, Placebo-Controlled Trial of a Cream Containing the Stryphnodendron Adstringens (Martius) Coville Bark Extract for Suppressing Terminal Hair Growth Journal of the European Academy of Dermatology and Venereology · 2009
    112. A Multicenter, Randomized, Placebo-Controlled, Double-Blind Clinical Trial of a Novel Formulation of 5% Minoxidil Topical Foam Versus Placebo in the Treatment of Androgenetic Alopecia in Men Journal of The American Academy of Dermatology · 2007
    113. Dihydrotestosterone-Inducible Dickkopf 1 from Balding Dermal Papilla Cells Causes Apoptosis in Follicular Keratinocytes Journal of Investigative Dermatology · 2007
    114. The Importance of Dual 5α-Reductase Inhibition in the Treatment of Male Pattern Hair Loss: Results of a Randomized Placebo-Controlled Study of Dutasteride Versus Finasteride Journal of The American Academy of Dermatology · 2006
    115. The Hair Growth Promoting Effect of Asiasari Radix Extract and Its Molecular Regulation Journal of Dermatological Science · 2005
    116. Minoxidil: Mechanisms of Action on Hair Growth British Journal of Dermatology · 2004
    117. The Hair Growth Promoting Effect of Sophora Flavescens Extract and Its Molecular Regulation Journal of Dermatological Science · 2002
    118. The Psychology of Hair Loss and Its Implications for Patient Care Clinics in Dermatology · 2001

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