Extract of Plumbago Zeylanica Enhances the Growth of Hair Follicle Dermal Papilla Cells with Down-Regulation of 5α-Reductase Type II

March 2020 in “ Journal of Cosmetic Dermatology ”

Noriko Yamada, Kensuke Miki, Yoko Yamaguchi, Yuki Takauji, Yoshimi Yamakami, Mohammad Nazir Hossain, Dai Ayusawa, Michihiko Fujii

Plumbago zeylanica plumbagin hair follicle dermal papilla cells 5α-reductase type II SRD5A2 androgenetic alopecia senescence DP cells Plumbago zeylanica extract hair follicle cells 5-alpha-reductase type II AGA

TLDR Plumbago zeylanica extract helps hair growth and reduces a hair loss-related enzyme.

The study focused on the role of senescence in hair follicle dermal papilla (DP) cells in androgenetic alopecia (AGA) and the therapeutic potential of Plumbago zeylanica extract. It was found that senescent DP cells up-regulated the expression of 5α-reductase type II (SRD5A2), an enzyme linked to AGA. The extract, particularly its component plumbagin, enhanced DP cell growth and down-regulated SRD5A2 expression. These findings suggest that Plumbago zeylanica extract and plumbagin could be beneficial in treating AGA by promoting DP cell growth and reducing SRD5A2 expression. The study was conducted on cultured human DP cells and did not involve human participants, with experiments performed in triplicate.

View this study on onlinelibrary.wiley.com →

Discuss this study in the Community →

Research cited in this study

13 / 13 results

research Bee Venom Promotes Hair Growth by Inhibiting 5α-Reductase Expression

15 citations, January 2016 in “Biological & Pharmaceutical Bulletin”

Bee venom helps hair grow and may work better than some common treatments.

research Oxidative Stress-Associated Senescence in Dermal Papilla Cells of Men with Androgenetic Alopecia

93 citations, February 2015 in “Journal of Investigative Dermatology”

Oxidative stress affects hair loss in men with androgenetic alopecia.

research Herbal Extracts Induce Dermal Papilla Cell Proliferation of Human Hair Follicles

24 citations, January 2015 in “Annals of Dermatology”

Herbal extracts may help hair grow and could be an alternative to synthetic hair loss treatments.

research Androgen Receptor Accelerates Premature Senescence of Human Dermal Papilla Cells in Association with DNA Damage

30 citations, November 2013 in “PLOS ONE”

Androgen receptor signaling causes early aging of cells important for hair growth by damaging their DNA.

research Dermal Papilla Cell Number Specifies Hair Size, Shape, and Cycling, and Its Reduction Causes Follicular Decline

211 citations, April 2013 in “Development”

More dermal papilla cells in hair follicles lead to larger, healthier hair, while fewer cells cause hair thinning and loss.

Scalable Production of Controllable Dermal Papilla Spheroids on PVA Surfaces and the Effects of Spheroid Size on Hair Follicle Regeneration

research Scalable Production of Controllable Dermal Papilla Spheroids on PVA Surfaces and the Effects of Spheroid Size on Hair Follicle Regeneration

78 citations, October 2012 in “Biomaterials”

Larger spheroids improve hair growth, but size doesn't guarantee thicker hair.

research Molecular Basis of Androgenetic Alopecia: From Androgen to Paracrine Mediators Through Dermal Papilla

122 citations, November 2010 in “Journal of Dermatological Science”

Male pattern baldness involves hormones and cell signals affecting hair growth.

research The Hair Growth Promoting Effect of Asiasari Radix Extract and Its Molecular Regulation

87 citations, March 2005 in “Journal of Dermatological Science”

Asiasari radix extract promotes hair growth and increases protein synthesis and cell proliferation.

research Androgenetic Alopecia in Men Aged 40-69 Years: Prevalence and Risk Factors

155 citations, December 2003 in “British Journal of Dermatology”

Hair loss increases with age; alcohol raises risk, more female partners lowers it.

research Finasteride Is the Main Inhibitor of 5α-Reductase Activity in Microdissected Dermal Papillae of Human Hair Follicles

28 citations, February 1999 in “Archives of Dermatological Research”

Finasteride potentially treats hair loss by reducing DHT production.

research Growth Factors in Hair Organ Development and the Hair Growth Cycle

90 citations, October 1996 in “Dermatologic Clinics”

Growth factors are crucial for hair development and could help treat hair diseases.

A Comparison of the Culture and Growth of Dermal Papilla Cells from Hair Follicles from Non-Balding and Balding (Androgenetic Alopecia) Scalp

research A Comparison of the Culture and Growth of Dermal Papilla Cells from Hair Follicles from Non-Balding and Balding (Androgenetic Alopecia) Scalp

19 citations, March 1996 in “British Journal of Dermatology”

Balding hair follicle cells are smaller, grow less well, and need more effort to culture than non-balding cells.

research Quantitative Study of the Human Hair Follicle in Normal Scalp and Androgenetic Alopecia

19 citations, August 1993 in “Journal of Cutaneous Pathology”

Alopecia causes smaller hair follicles and affects growth-related structures.

Related Research

7 / 7 results

research An Extract of Leontopodium Alpinum Prolongs Anagen Phase in Human Hair Follicles Ex Vivo

April 2021 in “Journal of Investigative Dermatology”

Leontopodium alpinum extract may help reduce hair shedding by keeping hair in the growth phase longer.

MiR-140-5p in Small Extracellular Vesicles From Human Papilla Cells Stimulates Hair Growth by Promoting Proliferation of Outer Root Sheath and Hair Matrix Cells

research MiR-140-5p in Small Extracellular Vesicles From Human Papilla Cells Stimulates Hair Growth by Promoting Proliferation of Outer Root Sheath and Hair Matrix Cells

18 citations, December 2020 in “Frontiers in cell and developmental biology”

miR-140-5p in certain cell vesicles helps hair growth by boosting cell proliferation.

research Two-Cell Assemblage Assay: A Simple In Vitro Method for Screening Hair Growth-Promoting Compounds

5 citations, November 2020 in “Frontiers in Cell and Developmental Biology”

The "Two-Cell Assemblage" assay is a new, simple method to identify substances that may promote hair growth.

research Extract of Plumbago Zeylanica Enhances the Growth of Hair Follicle Dermal Papilla Cells with Down-Regulation of 5α-Reductase Type II

4 citations, March 2020 in “Journal of Cosmetic Dermatology”

Plumbago zeylanica extract helps hair growth and reduces a hair loss-related enzyme.

research Maintaining Hair Inductivity in Human Dermal Papilla Cells: A Review of Effective Methods

35 citations, January 2020 in “Skin Pharmacology and Physiology”

The review concluded that keeping the hair-growing ability of human dermal papilla cells is key for hair development and growth.

research Hair Follicle Growth and Pigmentation During Aging

April 2018 in “Journal of Investigative Dermatology”

The research found that a specific skin cell type not only triggers hair growth but also controls hair color, and that aging can lead to hair loss and color changes.

research Beta-Catenin Activity in the Dermal Papilla Regulates Morphogenesis and Regeneration of Hair

314 citations, April 2010 in “Developmental Cell”

β-catenin in the dermal papilla is crucial for normal hair growth and repair.