Herbal Extracts Induce Dermal Papilla Cell Proliferation of Human Hair Follicles

    January 2015 in “ Annals of Dermatology ”
    Hossein Rastegar, Hamidreza Ahmadi Ashtiani, Mahmoud Aghaei, Behrooz Barikbin, Amirohushang Ehsani
    Image of study
    TLDR Herbal extracts may help hair grow and could be an alternative to synthetic hair loss treatments.
    In the 2015 study, researchers found that herbal extracts significantly increased the proliferation of human dermal papilla cells (DPCs), which are essential for hair growth, by affecting the expression of certain proteins and enzymes. The extracts increased cell viability and proliferation at concentrations between 1.5% and 4.5%, decreased the expression of 5-alpha-reductase type 2 (5-αR2) which is linked to hair loss, and modulated proteins involved in cell cycle progression and survival, such as Cyclin D1, Cdk4, Bcl-2, and Bax. The study suggests that these herbal extracts could be a potential alternative treatment for hair loss, offering benefits similar to synthetic drugs but with possibly fewer side effects. The experiments were performed in triplicate and repeated three to four times, with statistical significance set at p<0.05.
    Discuss this study in the Community →

    Research cited in this study

    9 / 9 results

    Related Community Posts Join

    6 / 73 results

      community Natural Remedies: Polyphenols and Hair Loss

       19 upvotes 5 years ago
      Natural remedies to treat hair loss, such as polyphenols, apple peel extract, grape seed extract, green tea extract, peppermint oil, pumpkin seed oil, apigenin, Ginkgo biloba, red clover extract, olive leaf extract, Ecklonia Cava and Grateloupia elliptica. In addition, terpenes, carotenoids, and tocopherols were discussed as potential treatments.

      community Looks like a real cure to the root of baldness (DHT-induced senescence) was proven earlier this year

      in Research/Science  742 upvotes 2 years ago
      A study that outlines the full model for androgenic alopecia (AGA) which links DHT to cellular senescence in dermal papilla cells, and suggests black chokeberry as a source of cyanidin 3-O-arabinoside polyphenol with potential anti-oxidant properties that could reverse this process. The post encourages reaching out to experts in anti-aging and longevity to research treatments involving the polyphenol.

      community HLT Megathread on HMI-115 (key takeaways in comments)

      in Research/Science  38 upvotes 1 year ago
      HMI-115, a newly discovered hair loss treatment that could potentially be effective for those with diffuse thinning and telogen effluvium. It is based on prolactin receptor antagonist signaling and has already undergone Phase I trials in women, with potential commercialization by 2027.

      community Here are the results from my journey! I used saw palmetto tablets instead of Finasteride(I was afraid of using it), 5% Minoxidil spray and Derma Pen once a week 1.5mm.

      in Progress Pictures  306 upvotes 1 year ago
      The user shared their positive hair regrowth experience using saw palmetto tablets, 5% minoxidil spray, and a Derma Pen. The conversation debates the effectiveness of saw palmetto versus finasteride, with some advocating for natural treatments and others emphasizing the proven results of finasteride and minoxidil, often in combination with microneedling.

      community Scientific evidence for Peppermint & Rosemary oils + My Experience

      in Research/Science  114 upvotes 2 years ago
      Natural treatments for hair loss, specifically peppermint oil and rosemary oil; how they can be used as a supplementary or alternative treatment to pharmaceuticals such as finasteride and minoxidil; and the personal experience of the user Divallo, who has seen an increase in density and thickness after using these oils for around 2.5 years. The post also touches on the potential antifungal properties of the oils and their effects on cutaneous blood flow.

    Similar Research

    6 / 1000+ results