Can Plant-Derived Phytochemicals Provide Symptom Relief for Hair Loss? A Critical Review

The 2019 review examined the potential of plant-derived phytochemicals in treating hair loss, focusing on human-based research. It discussed the pharmacological activities of compounds like caffeine and polyphenols, which may inhibit 5α-reductase and reduce dihydrotestosterone (DHT) levels, or provide antioxidant and anti-inflammatory benefits. The review highlighted studies on compounds such as procyanidin B-2, red ginseng extract, and others, with some showing increased hair count and improved hair growth in placebo-controlled trials. However, it noted the scarcity of clinical studies and the lack of standardized criteria for evaluating treatment effectiveness. The review concluded that while phytochemicals show promise, more robust clinical evidence is needed. Specific studies mentioned included a trial with 76 male patients showing increased hair count and thickness with pumpkin seed oil over 24 weeks, and studies with 60 AGA males and 72 healthy females showing improved hair density and reduced shedding. The document suggests that phytochemicals can promote hair growth and reduce hair loss through various mechanisms, but emphasizes the need for more rigorous clinical trials to validate their effectiveness.