The First Clinical Trial of Topical Application of Procyanidin B-2 to Investigate Its Potential as a Hair Growing Agent

    June 2001 in “ PTR. Phytotherapy research/Phytotherapy research ”
    Tomoya Takahashi, Ayako Kamimura, Yoshiharu Yokoo … Y. Watanabe
    Studysummary This study reported that a 1% procyanidin B-2 tonic increased hair diameter and density in men with male pattern baldness, suggesting it may be a potential treatment option.
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    Research cited in this study 13

    1. Toxicological Studies on Procyanidin B-2 for External Application as a Hair Growing Agent Food and chemical toxicology · 1999
    2. Procyanidin Oligomers Selectively and Intensively Promote Proliferation of Mouse Hair Epithelial Cells In Vitro and Activate Hair Follicle Growth In Vivo ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 1999
    3. Acquired Scalp Alopecia: A Review Australasian Journal of Dermatology · 1998
    4. Proanthocyanidins from Grape Seeds Promote Proliferation of Mouse Hair Follicle Cells In Vitro and Convert Hair Cycle In Vivo Acta dermato-venereologica · 1998
    5. Natural Progression of Male Pattern Baldness in Young Men Clinical and Experimental Dermatology · 1991
    6. Quantitative Estimation of Hair Growth: Androgenetic Alopecia in Women and the Effect of Minoxidil Journal of Investigative Dermatology · 1990
    7. Biochemical and Trichological Characterization of Diffuse Alopecia in Women British Journal of Dermatology · 1990
    8. Quantitative Assessment of 2% Topical Minoxidil in the Treatment of Male Pattern Baldness Clinical and Experimental Dermatology · 1989
    9. Topical Minoxidil in Early Androgenetic Alopecia Journal of The American Academy of Dermatology · 1987
    10. Androgenetic Alopecia: Treatment Results with Topical Minoxidil Journal of The American Academy of Dermatology · 1987
    11. Use of Topical Minoxidil in the Treatment of Male Pattern Baldness Journal of The American Academy of Dermatology · 1987
    12. The Unit Area Trichogram in the Assessment of Androgen-Dependent Alopecia British Journal of Dermatology · 1983
    13. Hair Diameter in Female Baldness British Journal of Dermatology · 1972