The First Clinical Trial of Topical Application of Procyanidin B-2 to Investigate Its Potential as a Hair Growing Agent

The study investigated the hair-growing effects of a 1% procyanidin B-2 tonic over 4 months in a double-blind clinical trial with 29 male subjects (19 using procyanidin B-2 and 10 using a placebo). No adverse side effects were observed. Results showed that 78.9% of the procyanidin B-2 group experienced an increase in hair diameter compared to 30.0% in the placebo group (p < 0.02). Additionally, the procyanidin B-2 group had a significantly higher increase in hairs measuring more than 40 μm in diameter and a greater increase in total hair count in a designated scalp area (0.25 cm²) compared to the placebo group (p < 0.05 and p < 0.001, respectively). The findings suggested that procyanidin B-2 could be a promising treatment for male pattern baldness.