Human Hair Follicle and Epidermal Melanocytes Exhibit Striking Differences in Their Aging Profile Involving Catalase

    December 2010 in “ ˜The œjournal of investigative dermatology/Journal of investigative dermatology ”
    Söbia Kauser, Gillian Westgate, Martin R. Green, Desmond J. Tobin
    TLDR Hair follicle cells age faster and lose pigment due to less catalase, causing hair to turn gray.
    The study revealed that human hair follicle melanocytes (HFMs) and epidermal melanocytes (EMs) aged differently, with HFMs showing a more significant decline in proliferation and tyrosinase expression. Catalase expression and activity, important for reducing oxidative stress, were markedly lower in older HFMs, indicating a higher vulnerability to oxidative damage, which may contribute to hair graying. The findings suggested that oxidative stress significantly influenced hair follicle aging and graying, with catalase playing a crucial role in this process.
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