Aging of the Hair Follicle Pigmentation System

    January 2009 in “ International journal of trichology ”
    Desmond J. Tobin
    Image of study
    TLDR Hair grays due to oxidative stress and fewer functioning melanocytes.
    The document discussed the aging of the hair follicle pigmentation system, focusing on the mechanisms behind hair graying. It highlighted that oxidative stress and the accumulation of reactive oxygen species (ROS) played significant roles in melanocyte degeneration, leading to decreased melanin production. The study noted that graying hair follicles had reduced numbers of functioning melanocytes and impaired antioxidant systems. Additionally, it mentioned that the onset and progression of graying correlated with chronological aging and were genetically controlled. The research suggested that the high melanin production capacity and associated oxidative stress might contribute to melanocyte degeneration. The document also explored the potential for recruiting amelanotic melanocytes for hair repigmentation and noted the impact of graying hair on the cosmetics industry.
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