Hair Follicle Pigmentation: Mechanisms and Factors Influencing Melanin Production
January 2005
in “
The journal of investigative dermatology/Journal of investigative dermatology
”
hair follicle pigmentation melanocytes keratinocytes dermal papilla fibroblasts follicular melanogenesis melanin anagen stage catagen stage telogen stage melanin synthesis signal transduction pathways hormonal signals receptors ligands hair pigmentation melanin production hair growth stages hormone signals
TLDR Hair color is determined by melanin produced and transferred in hair follicles.
The document "Hair Follicle Pigmentation" from January 1, 2005, examined the mechanisms and factors influencing hair follicle pigmentation, focusing on the role of melanocytes in melanin production. It discussed the genetic and environmental factors affecting melanocyte function, the biochemical pathways of melanin synthesis, and the changes in hair pigmentation over time, such as graying. The study highlighted the importance of enzymes like tyrosinase, the role of melanocyte stem cells, and the regulatory mechanisms involving hormones and cytokines. It also noted the sensitivity of follicular melanocytes to aging and the potential for therapeutic interventions to influence hair color and treat pigmentation disorders.
