Nudging Hair Shedding by Antidandruff Shampoos: A Comparison of 1% Ketoconazole, 1% Piroctone Olamine, and 1% Zinc Pyrithione Formulations

October 2002 in “ International Journal of Cosmetic Science ”

Piérard-Franchimont C, Véronique Goffin, Frédérique Henry, Isabelle Uhoda, C. Braham, Gérald Pierard

ketoconazole piroctone olamine zinc pyrithione telogen effluvium androgenic alopecia pruritus dandruff hair shedding hair shaft diameter sebum output KTZ PTO ZPT

Studysummary This study found that 1% ketoconazole and 1% piroctone olamine shampoos increased hair shaft thickness and reduced hair shedding in men with telogen effluvium and androgenic alopecia associated with dandruff. Our plain-language summary of this paper — not a Tressless recommendation.

In a 2002 study involving 150 men with telogen effluvium related to androgenic alopecia and dandruff, the efficacy of three antidandruff shampoos with 1% concentrations of ketoconazole (KTZ), piroctone olamine (PTO), and zinc pyrithione (ZPT) was evaluated. The men were divided into three groups of 50 and used their assigned shampoo 2-3 times a week for 6 months. The study concluded that all shampoos were effective in reducing pruritus, dandruff, and hair shedding, with KTZ and PTO also increasing hair shaft diameter and slightly decreasing sebum output, unlike ZPT. This suggests that while all three shampoos can control telogen effluvium, KTZ and PTO may offer additional benefits in improving hair shaft thickness.

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