Androgenetic Alopecia and Microinflammation

August 2000 in “ International Journal of Dermatology ”

Yann Mahe, Jean-François Michelet, Nelly Billoni, Francoise Jarrousse, Bruno Buan, Stephane Commo, Didier Saint-Leger, Bruno Bernard

androgenetic alopecia microinflammation testosterone 5-DHT inflammation hormone synthesis AGA DHT

Studysummary Inflammation may be linked to hair loss, and targeting specific enzymes could help treat it.

Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer

The article explores the potential connection between microinflammation and androgenetic alopecia (AGA), a type of hair loss caused by testosterone and its derivative 5-DHT. Studies suggest that inflammation may be involved in AGA, and treating inflammation could be a possible solution for AGA. The paper proposes targeting certain enzymes involved in hormone synthesis and microinflammation as potential treatments for AGA. However, further research is needed to fully comprehend the relationship between inflammation and AGA.

View this study on onlinelibrary.wiley.com →

Discuss this study in the Community →

Research cited in this study

15 / 15 results

research Genetic Analysis of Male Pattern Baldness and the 5α-Reductase Genes

169 citations , June 1998 in “Journal of Investigative Dermatology”

This study found no significant genetic association between the 5α-reductase enzyme genes and male pattern baldness, suggesting a polygenic etiology rather than simple inheritance.

Different Levels of 5α-Reductase Type I and II, Aromatase, and Androgen Receptor in Hair Follicles of Women and Men with Androgenetic Alopecia

research Different Levels of 5α-Reductase Type I and II, Aromatase, and Androgen Receptor in Hair Follicles of Women and Men with Androgenetic Alopecia

416 citations , September 1997 in “Journal of Investigative Dermatology”

People with hair loss have more androgen receptors and enzymes in certain follicles, with men and women showing different patterns.

research Alopecia: The Search for Novel Agents Continues

11 citations , August 1997 in “Expert Opinion on Therapeutic Patents”

This review discusses nearly 70 patent applications for the treatment of androgenetic alopecia and other hair conditions, highlighting the mechanisms of action explored but reports no clinical results.

Activation of Cytoprotective Prostaglandin Synthase-1 by Minoxidil as a Possible Explanation for Its Hair Growth-Stimulating Effect

research Activation of Cytoprotective Prostaglandin Synthase-1 by Minoxidil as a Possible Explanation for Its Hair Growth-Stimulating Effect

81 citations , February 1997 in “Journal of Investigative Dermatology”

This study suggests that minoxidil activates PGHS-1, which may explain its hair growth-stimulating effects and could aid in designing more potent hair growth-promoting drugs.

Inhibition of Hair Growth by Testosterone in the Presence of Dermal Papilla Cells from the Frontal Bald Scalp of the Postpubertal Stumptailed Macaque

research Inhibition of Hair Growth by Testosterone in the Presence of Dermal Papilla Cells from the Frontal Bald Scalp of the Postpubertal Stumptailed Macaque

19 citations , January 1997 in “Endocrinology”

This study observed that testosterone inhibits hair follicle epithelial cell proliferation in adult stumptailed macaques only when dermal papilla cells from bald scalps are present, with antiandrogen RU 58841 reversing this effect.

research Chronic Telogen Effluvium: Increased Scalp Hair Shedding in Middle-Aged Women

234 citations , December 1996 in “Journal of The American Academy of Dermatology”

The authors concluded that chronic telogen effluvium in middle-aged women presents distinct clinical and histological features that differ from androgenetic alopecia and acute telogen effluvium.

research Improvement in the Inflammatory Aspect of Androgenetic Alopecia: A Pilot Study with an Antimicrobial Lotion

40 citations , January 1996 in “Journal of Dermatological Treatment”

This study found that using an antimicrobial lotion for 18 months may reduce inflammation and potentially partially reverse hair loss in men with androgenetic alopecia.

research Novel Cycle Changes in Scalp Hair Are Caused by Etretinate Therapy

24 citations , March 1995 in “British Journal of Dermatology”

This study reported that etretinate treatment leads to increased hair shedding due to a sustained decrease in anagen duration, with an arrest at the onset of anagen and a follicular anchorage defect in telogen contributing to alopecia.

research Androgenetic Alopecia: An Autosomal Dominant Disorder

80 citations , January 1995 in “The American Journal of Medicine”

Hair loss in androgenetic alopecia is caused by genetic factors and androgen excess, and can be treated with combined therapies.

research Biphasic Effect of 1,25-Dihydroxyvitamin D3 on Human Hair Follicle Growth and Hair Fiber Production in Whole-Organ Cultures

27 citations , September 1994 in “The journal of investigative dermatology/Journal of investigative dermatology”

This study found that relatively low concentrations of 1,25(OH)2D3 stimulated human hair follicle and fiber growth, while higher concentrations inhibited growth in a whole-organ culture system.

research Changes in Populations of HLA-DR+CD3+ Cells and CD57–CD16+ Cells in Alopecia Areata After Corticosteroid Therapy

5 citations , January 1994 in “Dermatology”

This study found that severe forms of alopecia areata showed increased activated T cells and natural killer cells, which decreased after corticosteroid treatment, correlating with disease activity and hair regrowth.

research Diagnostic and Predictive Value of Horizontal Sections of Scalp Biopsy Specimens in Male Pattern Androgenetic Alopecia

309 citations , May 1993 in “Journal of The American Academy of Dermatology”

This study concluded that horizontal sections of scalp biopsy specimens provide more diagnostic information for male pattern androgenetic alopecia than vertical sections and can predict hair regrowth potential following topical minoxidil therapy.

research Glucocorticoid Effect on Hair Growth Initiation: A Reconsideration

77 citations , January 1993 in “Skin Pharmacology and Physiology”

In this study, topically applied glucocorticosteroids were found to block hair growth at the stage of hair formation, but not the initiation of hair growth, in a mouse model.

research The Transverse Anatomy of Androgenic Alopecia

42 citations , December 1990 in “The Journal of Dermatologic Surgery and Oncology”

This study found decreased hair density and altered follicular architecture in the balding frontal scalp of patients with androgenic alopecia, with increased vellus hairs noted.

research Male Pattern Alopecia: A Histopathologic and Histochemical Study

94 citations , August 1975 in “Journal of Cutaneous Pathology”

In this study, the researchers observed that male pattern alopecia is characterized by miniature follicles, enlarged sebaceous glands, and an increased number of mast cells, without significant abnormalities in enzyme activity.