Androgenetic Alopecia and Microinflammation

August 2000 in “ International Journal of Dermatology ”

Yann Mahe, Jean-François Michelet, Nelly Billoni, Francoise Jarrousse, Bruno Buan, Stephane Commo, Didier Saint-Leger, Bruno Bernard

androgenetic alopecia microinflammation testosterone 5-DHT inflammation hormone synthesis AGA DHT

TLDR Inflammation may be linked to hair loss, and targeting specific enzymes could help treat it.

The article explores the potential connection between microinflammation and androgenetic alopecia (AGA), a type of hair loss caused by testosterone and its derivative 5-DHT. Studies suggest that inflammation may be involved in AGA, and treating inflammation could be a possible solution for AGA. The paper proposes targeting certain enzymes involved in hormone synthesis and microinflammation as potential treatments for AGA. However, further research is needed to fully comprehend the relationship between inflammation and AGA.

View this study on onlinelibrary.wiley.com →

Discuss this study in the Community →

Research cited in this study

14 / 14 results

Different Levels of 5α-Reductase Type I and II, Aromatase, and Androgen Receptor in Hair Follicles of Women and Men with Androgenetic Alopecia

research Different Levels of 5α-Reductase Type I and II, Aromatase, and Androgen Receptor in Hair Follicles of Women and Men with Androgenetic Alopecia

416 citations , September 1997 in “Journal of Investigative Dermatology”

People with hair loss have more androgen receptors and enzymes in certain follicles, with men and women showing different patterns.

research Alopecia: The Search for Novel Agents Continues

11 citations , August 1997 in “Expert Opinion on Therapeutic Patents”

Many potential alopecia treatments need more testing to confirm they promote acceptable hair growth with minimal side effects.

Activation of Cytoprotective Prostaglandin Synthase-1 by Minoxidil as a Possible Explanation for Its Hair Growth-Stimulating Effect

research Activation of Cytoprotective Prostaglandin Synthase-1 by Minoxidil as a Possible Explanation for Its Hair Growth-Stimulating Effect

81 citations , February 1997 in “Journal of Investigative Dermatology”

Minoxidil boosts hair growth by activating PGHS-1.

Inhibition of Hair Growth by Testosterone in the Presence of Dermal Papilla Cells from the Frontal Bald Scalp of the Postpubertal Stumptailed Macaque

research Inhibition of Hair Growth by Testosterone in the Presence of Dermal Papilla Cells from the Frontal Bald Scalp of the Postpubertal Stumptailed Macaque

19 citations , January 1997 in “Endocrinology”

Testosterone can slow hair growth in adult monkeys, but a blocker called RU 58841 can counteract this and potentially help hair regrow.

research Chronic Telogen Effluvium: Increased Scalp Hair Shedding in Middle-Aged Women

234 citations , December 1996 in “Journal of The American Academy of Dermatology”

Middle-aged women with chronic telogen effluvium experience increased hair shedding but usually don't get significantly thinner hair.

research Improvement in the Inflammatory Aspect of Androgenetic Alopecia: A Pilot Study with an Antimicrobial Lotion

40 citations , January 1996 in “Journal of Dermatological Treatment”

Antimicrobial lotion reduces inflammation and increases hair density in hair loss patients.

research Novel Cycle Changes in Scalp Hair Are Caused by Etretinate Therapy

24 citations , March 1995 in “British Journal of Dermatology”

Etretinate therapy can cause hair loss by disrupting the hair growth cycle.

research Androgenetic Alopecia: An Autosomal Dominant Disorder

80 citations , January 1995 in “The American Journal of Medicine”

Hair loss in androgenetic alopecia is caused by genetic factors and androgen excess, and can be treated with combined therapies.

research Biphasic Effect of 1,25-Dihydroxyvitamin D3 on Human Hair Follicle Growth and Hair Fiber Production in Whole-Organ Cultures

27 citations , September 1994 in “The journal of investigative dermatology/Journal of investigative dermatology”

Small amounts of Vitamin D3 can boost hair growth, but too much can stop it.

research Changes in Populations of HLA-DR+CD3+ Cells and CD57–CD16+ Cells in Alopecia Areata After Corticosteroid Therapy

5 citations , January 1994 in “Dermatology”

Corticosteroid therapy reduces specific immune cells and promotes hair growth in alopecia areata patients.

research Diagnostic and Predictive Value of Horizontal Sections of Scalp Biopsy Specimens in Male Pattern Androgenetic Alopecia

309 citations , May 1993 in “Journal of The American Academy of Dermatology”

Horizontal scalp biopsy sections effectively diagnose and predict MPAA, with follicular density and inflammation impacting hair regrowth.

research Glucocorticoid Effect on Hair Growth Initiation: A Reconsideration

77 citations , January 1993 in “Skin Pharmacology and Physiology”

Steroids stop hair growth temporarily but don't block the signals that start it.

research The Transverse Anatomy of Androgenic Alopecia

42 citations , December 1990 in “The Journal of Dermatologic Surgery and Oncology”

The study found that horizontal sections of scalp biopsies are better for analyzing hair loss, showing fewer hairs and more fine hairs in balding areas.

research Male Pattern Alopecia: A Histopathologic and Histochemical Study

94 citations , August 1975 in “Journal of Cutaneous Pathology”

Male pattern baldness involves smaller hair follicles, larger oil glands, and other tissue changes, but not major blood supply issues.

Similar Research

5 / 1000+ results

research Bioactive Compound-Loaded Nanocarriers for Hair Growth Promotion: Current Status and Future Perspectives

October 2023 in “Plants”

Nanocarriers with plant extracts show promise for safe and effective hair growth treatment.

research Efficacy and Mechanism of Topical Shen Bai Hair Growing Decoction Against Androgenetic Alopecia

February 2024 in “ACS Omega”

The Shen Bai Hair Growing Decoction may help treat hair loss by promoting hair growth and reducing inflammation.

research Clinical And Preclinical Approach In AGA Treatment: A Review Of Current And New Therapies In The Regenerative Field

August 2024 in “Stem Cell Research & Therapy”

New regenerative therapies show promise for treating hair loss.

research Female Pattern Hair Loss: An Update

12 citations , January 2020 in “Indian Dermatology Online Journal”

Female pattern hair loss has multiple causes and treatments, with new therapies showing promise.

research An Updated Etiology of Hair Loss and the New Cosmeceutical Paradigm in Therapy: Clearing the Big Eight Strikes

July 2023 in “Cosmetics”

New treatments for hair loss should target eight main causes and use specific plant compounds and peptides for better results.