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    Research 10 of 1000+

    1. Unscrewing DHT-Blocking Properties of Allium Cepa Extract: Virtual Screening of active Compounds against 5-Alpha Reductase and Evaluation of Adme/T Properties of Compounds Zenodo (CERN European Organization for Nuclear Research) · 2023 · 1 citations
    2. Topical MK-386 (M), an inhibitor of 5α-reductase (5αr) type I, suppresses sebum dht. Clinical Pharmacology & Therapeutics · 1996
    3. Sexual dimorphism of growth plate prehypertrophic and hypertrophic chondrocytes in response to testosterone requires metabolism to dihydrotestosterone (DHT) by steroid 5‐alpha reductase type 1 Journal of Cellular Biochemistry · 2005 · 27 citations
    4. Pharmacokinetic parameters and mechanisms of inhibition of rat type 1 and 2 steroid 5α-reductases: determinants for different in vivo activities of GI198745 and finasteride in the rat 3 3Abbreviations: r5AR1, rat 5α-reductase 1; r5AR2, rat 5α-reductase 2; and DHT, dihydrotestosterone. Biochemical Pharmacology · 2001 · 22 citations
    5. Dutasteride, a novel dual 5-A reductase inhibitor, reduces serum DHT to a greater extent versus finasteride and achieves finasteride maximal reduction in a larger proportion of patients European Urology Supplements · 2003 · 12 citations
    6. An isotope dilution-liquid chromatography-tandem mass spectrometry-based candidate reference measurement procedure for the quantification of 5-alpha-dihydrotestosterone in human serum and plasma Clinical Chemistry and Laboratory Medicine (CCLM) · 2026
    7. The biochemical and phenotypic characterization of females homozygous for 5 alpha-reductase-2 deficiency. The Journal of Clinical Endocrinology & Metabolism · 1995 · 54 citations
    8. Comparative Efficacy of Oral and Topical 5-Alpha Reductase Inhibitors in Reducing Dihydrotestosterone levels across Men with Androgenetic Alopecia: A Network Meta-Analysis incorporating Post-Hoc Analyses of Randomized Clinical Trial Data Open Science Framework · 2026
    9. 5 Alpha - Reductase and Metabolic Syndrome in PCOS Patients International Journal of Science and Research (IJSR) · 2021
    10. Overexpression of aldo-keto reductase 1C3 (AKR1C3) in LNCaP cells diverts androgen metabolism towards testosterone resulting in resistance to the 5α-reductase inhibitor finasteride The Journal of Steroid Biochemistry and Molecular Biology · 2012 · 45 citations
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    Community 10 of 1000+

    1. Approximation of Scalp DHT Suppression Between 0.05 mg to 2.5 mg Reddit · 28 Jan 2024
    2. Is there any role for topical DHT antagonists, or does a 5-AR inhibitor remove the need for them as therapy Reddit · 6 Jan 2025
    3. Increasing DHT level after 5 months of Finasteride Reddit · 19 Sept 2024
    4. DHT Gel (2.5%) to beard area + Dut + Pyri 1% + Minox Reddit · 27 Sept 2025
    5. Dutasteride 0.5 mg/day lowers scalp DHT levels by only 50% (but 2.5 mg/day lowers scalp DHT by 80%). Reddit · 21 Feb 2025
    6. Drastic loss after stabilization for 5 years of DHT blockers, topical minoxidil, nizoral shampoo Reddit · 29 Mar 2025
    7. Is this insufficient reduction of DHT while being on fin for 5 years? Reddit · 17 Apr 2026
    8. DHT levels after 10 months on dut 0.5 ed, how is this even possible? Reddit · 1 Nov 2025
    9. How can any shampoo stop hair loss,block dht in just 5 minutes of being on scalp ? Reddit · 4 Oct 2024
    10. Studies show: 0.2 mg reduces scalp DHT by ~55%. 1 mg reduces it by ~64%. 5 mg reduces it by ~69%. Reddit · 9 Oct 2025
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    Learn 10 of 24

    1. Finasteride Popular 5-alpha reductase inhibitor that lowers DHT, taken as a pill or used topically
    2. Dutasteride 5-alpha reductase inhibitor that blocks both enzyme types, a stronger DHT blocker than finasteride
    3. Cyproterone a synthetic anti-androgen and weak progestogen that inhibits DHT binding to androgen receptor
    4. Pyrilutamide Experimental topical anti-androgen, also known as KX-826
    5. Clascoterone Topical androgen-receptor blocker, approved as an acne cream
    6. Saw Palmetto Palm-berry extract taken as a supplement
    7. Azelaic Acid Acid used in acne and rosacea creams
    8. Rosemary Herb whose oil is used in hair care
    9. Neem Oil Oil from the neem tree, used in traditional remedies
    10. Biopeptide-5
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