Genetics and Other Factors in the Etiology of Female Pattern Hair Loss

    April 2017 in “ Experimental Dermatology
    Silke Redler, Andrew G. Messenger, Regina C. Betz
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    TLDR Female pattern hair loss has unclear causes, possibly involving genetics, hormones, and environment, and needs better treatments.
    Female pattern hair loss (FPHL) is a common hair loss disorder in women, with a prevalence that increases with age. While male pattern hair loss (M-AGA) is an androgen-dependent trait that is predominantly genetically determined, the role of androgens in causing FPHL is less clear. Genome-wide association studies (GWASS) have identified several genetic loci for M-AGA, but the role of heritable factors in FPHL is largely unknown. Recently published studies suggest that the aetiology of FPHL differs substantially from that of M-AGA, and other non-androgenic pathways, including environmental influences, may contribute to the aetiology. Current therapies for FPHL are unsatisfactory, and there is a demand for new treatment strategies.
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