Investigation of Four Novel Male Androgenetic Alopecia Susceptibility Loci: No Association with Female Pattern Hair Loss

December 2013 in “ Archives of Dermatological Research ”

Rima Nuwaihyd, Silke Redler, Stefanie Heilmann, Dmitriy Drichel, Sabrina Wolf, Pattie Birch, K. Dobson, Gerhard Lutz, Kathrin A. Giehl, Roland Kruse, Rachid Tazi-Ahnini, Sandra Hanneken, Markus Böhm, Anja Miesel, Tobias Fischer, Hans Wolff, Tim Becker, Natalie Garcia-Bartels, Ulrike Blume-Peytavi, Markus M. Nöthen, Andrew G. Messenger, Regina C. Betz

androgenetic alopecia female pattern hair loss AGA FPHL genotyped variants susceptibility loci male pattern baldness female hair thinning

TLDR No link found between new male baldness genes and female hair loss.

This study investigated the association between four newly identified male androgenetic alopecia susceptibility loci and female pattern hair loss (FPHL). The study found no significant association between the genotyped variants and FPHL, providing no support for the hypothesis that the novel AGA loci influence susceptibility to FPHL. The study also discussed the incomplete understanding of the etiology of FPHL and the hypothesis of a shared genetic background between FPHL and AGA.

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Research cited in this study

16 / 16 results

research Investigation of Six Novel Susceptibility Loci for Male Androgenetic Alopecia in Women With Female Pattern Hair Loss

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research Selected Variants of the Steroid-5-Alpha-Reductase Isoforms SRD5A1 and SRD5A2 and the Sex Steroid Hormone Receptors ESR1, ESR2, and PGR: No Association with Female Pattern Hair Loss Identified

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No link found between specific genes and female pattern hair loss.

research Investigation of the Male Pattern Baldness Major Genetic Susceptibility Loci AR/EDA2R and 20p11 in Female Pattern Hair Loss

38 citations, February 2012 in “British Journal of Dermatology”

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research Association Analysis of Estrogen Receptor Beta Gene (ESR2) Polymorphisms with Female Pattern Hair Loss

27 citations, October 2011 in “British Journal of Dermatology”

ESR2 gene variations may be linked to female pattern hair loss.

research Investigation of Variants of the Aromatase Gene (CYP19A1) in Female Pattern Hair Loss

15 citations, June 2011 in “British Journal of Dermatology”

No link found between aromatase gene and female hair loss.

research Fine Mapping of the Human AR/EDA2R Locus in Androgenetic Alopecia

28 citations, April 2010 in “British Journal of Dermatology”

Genetic marker rs12558842 strongly linked to male hair loss.

research Gene-Wide Association Study Between the Aromatase Gene (CYP19A1) and Female Pattern Hair Loss

77 citations, April 2009 in “British Journal of Dermatology”

Aromatase gene variation may increase female hair loss risk.

research Prevalence of Male and Female Pattern Hair Loss in Maryborough

193 citations, August 2005 in “Journal of Investigative Dermatology Symposium Proceedings”

Hair loss common in Australia; men affected earlier, more often than Asians; women less concerned.

research The Reliability of Horizontally Sectioned Scalp Biopsies in the Diagnosis of Chronic Diffuse Telogen Hair Loss in Women

137 citations, July 2004 in “Journal of The American Academy of Dermatology”

Horizontally sectioned scalp biopsies are more reliable for diagnosing hair loss in women when three samples are taken instead of one.

research Hair Density, Hair Diameter, and the Prevalence of Female Pattern Hair Loss

234 citations, February 2001 in “British Journal of Dermatology”

FPHL affects hair density and diameter, causing visible hair loss in older women.

research Incidence of Female Androgenetic Alopecia (Female Pattern Alopecia)

89 citations, January 2001 in “Dermatologic Surgery”

Hair loss in women is common, starts in late 20s, and affects 30% of women over 50.

research Role of Androgens in Female-Pattern Androgenetic Alopecia, Either Alone or Associated with Other Symptoms of Hyperandrogenism

47 citations, December 2000 in “Archives of Dermatological Research”

Androgens significantly affect female hair loss, and hormonal treatments may help.

research WNT Signaling in the Control of Hair Growth and Structure

271 citations, March 1999 in “Developmental biology”

The research shows that a gene called Wnt3 affects hair growth and structure, causing short hair and balding when overactive.

research Classification of the Types of Androgenetic Alopecia (Common Baldness) Occurring in the Female Sex

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Common baldness, also known as Androgenetic Alopecia, is caused by a combination of genetic factors and hormones called androgens.

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community Diffuse hair loss and scalp biopsies

in Research 692 upvotes 4 months ago

Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

community One+ year 1mg Fin, Ketoconazole, and 3.75 Oral Min. I have DUPA. Switched from Topical to Oral Min.

in Progress Pictures 142 upvotes 2 years ago

A user's experience with hair loss treatments such as finasteride, ketoconazole, and oral minoxidil that have not yielded any results; other users suggest shaving the head or getting a wig, while others offer additional advice such as seeing a dermatologist, checking thyroid levels, switching to dutasteride and adding needling, and trying stemoxydine.

community Diagnosed with female pattern hair loss as a male with recent aggressive loss. Preemptively mourning the only part of myself I’ve ever come close to loving. Lost all motivation to do anything with my life.

in Progress Pictures 271 upvotes 1 year ago

The conclusion of the conversation is that the user should consider using treatments such as finasteride, minoxidil, and RU58841 to potentially reverse their hair loss. Other suggestions include using hair loss concealers and maintaining a healthy diet.

community Finasteride 5mg for female pattern hair loss

in Female 7 upvotes 4 years ago

The user's experience of using Finasteride 5mg and Aldactone 50mg to treat Female Pattern Hair Loss, as well as their use of PRP injections for further hair growth.

community Female, 27 years old, shedding/ balding despite being on what is considered to be a effective treatment plan for AGA. Considering Dut (oral) . Please help.

in Finasteride/Dutasteride 27 upvotes 2 months ago

A 27-year-old woman with androgenic alopecia is losing hair despite using oral minoxidil and spironolactone, and is considering dutasteride. She is exploring causes like stress and medication side effects, planning tests, and considering treatment changes.

community I am a dermatologist with a clinical interest in alopecia. AMA

in Will treatment work for me? 2 years ago

In this conversation, 4990 discussed various treatments for hair loss, including oral minoxidil, PRP, transplan, Jak inhibitors, Dutasteride, Finasteride, Olumiant, Ketoconazole, RU58841, microneedling, baricitinib, and CCCA. They recommended scalp biopsies in unclear cases of DUPA, twice weekly to twice daily shampooing for topical minoxidil users, and two sessions spaced one month apart with follow up at month three to determine the effectiveness of PRP treatment.

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research Investigation of Four Novel Male Androgenetic Alopecia Susceptibility Loci: No Association with Female Pattern Hair Loss

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