Investigation of Four Novel Male Androgenetic Alopecia Susceptibility Loci: No Association with Female Pattern Hair Loss

December 2013 in “ Archives of Dermatological Research ”

Rima Nuwaihyd, Silke Redler, Stefanie Heilmann, Dmitriy Drichel, Sabrina Wolf, Pattie Birch, K. Dobson, Gerhard Lutz, Kathrin A. Giehl, Roland Kruse, Rachid Tazi-Ahnini, Sandra Hanneken, Markus Böhm, Anja Miesel, Tobias Fischer, Hans Wolff, Tim Becker, Natalie Garcia-Bartels, Ulrike Blume-Peytavi, Markus M. Nöthen, Andrew G. Messenger, Regina C. Betz

androgenetic alopecia female pattern hair loss AGA FPHL genotyped variants susceptibility loci male pattern baldness female hair thinning

TLDR No link found between new male baldness genes and female hair loss.

This study investigated the association between four newly identified male androgenetic alopecia susceptibility loci and female pattern hair loss (FPHL). The study found no significant association between the genotyped variants and FPHL, providing no support for the hypothesis that the novel AGA loci influence susceptibility to FPHL. The study also discussed the incomplete understanding of the etiology of FPHL and the hypothesis of a shared genetic background between FPHL and AGA.

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Research cited in this study

16 / 16 results

research Investigation of Six Novel Susceptibility Loci for Male Androgenetic Alopecia in Women With Female Pattern Hair Loss

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research Investigation of the Male Pattern Baldness Major Genetic Susceptibility Loci AR/EDA2R and 20p11 in Female Pattern Hair Loss

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research Association Analysis of Estrogen Receptor Beta Gene (ESR2) Polymorphisms with Female Pattern Hair Loss

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ESR2 gene variations may be linked to female pattern hair loss.

research Investigation of Variants of the Aromatase Gene (CYP19A1) in Female Pattern Hair Loss

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research Fine Mapping of the Human AR/EDA2R Locus in Androgenetic Alopecia

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Genetic marker rs12558842 strongly linked to male hair loss.

research Gene-Wide Association Study Between the Aromatase Gene (CYP19A1) and Female Pattern Hair Loss

77 citations, April 2009 in “British Journal of Dermatology”

Aromatase gene variation may increase female hair loss risk.

research Prevalence of Male and Female Pattern Hair Loss in Maryborough

193 citations, August 2005 in “Journal of Investigative Dermatology Symposium Proceedings”

Hair loss common in Australia; men affected earlier, more often than Asians; women less concerned.

research The Reliability of Horizontally Sectioned Scalp Biopsies in the Diagnosis of Chronic Diffuse Telogen Hair Loss in Women

137 citations, July 2004 in “Journal of The American Academy of Dermatology”

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research Hair Density, Hair Diameter, and the Prevalence of Female Pattern Hair Loss

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FPHL affects hair density and diameter, causing visible hair loss in older women.

research Incidence of Female Androgenetic Alopecia (Female Pattern Alopecia)

89 citations, January 2001 in “Dermatologic Surgery”

Hair loss in women is common, starts in late 20s, and affects 30% of women over 50.

research Role of Androgens in Female-Pattern Androgenetic Alopecia, Either Alone or Associated with Other Symptoms of Hyperandrogenism

47 citations, December 2000 in “Archives of Dermatological Research”

Androgens significantly affect female hair loss, and hormonal treatments may help.

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community Diffuse hair loss and scalp biopsies

in Research 692 upvotes 3 months ago

Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

community One+ year 1mg Fin, Ketoconazole, and 3.75 Oral Min. I have DUPA. Switched from Topical to Oral Min.

in Progress Pictures 142 upvotes 2 years ago

A user's experience with hair loss treatments such as finasteride, ketoconazole, and oral minoxidil that have not yielded any results; other users suggest shaving the head or getting a wig, while others offer additional advice such as seeing a dermatologist, checking thyroid levels, switching to dutasteride and adding needling, and trying stemoxydine.

community Diagnosed with female pattern hair loss as a male with recent aggressive loss. Preemptively mourning the only part of myself I’ve ever come close to loving. Lost all motivation to do anything with my life.

in Progress Pictures 271 upvotes 1 year ago

The conclusion of the conversation is that the user should consider using treatments such as finasteride, minoxidil, and RU58841 to potentially reverse their hair loss. Other suggestions include using hair loss concealers and maintaining a healthy diet.

community Finasteride 5mg for female pattern hair loss

in Female 7 upvotes 4 years ago

The user's experience of using Finasteride 5mg and Aldactone 50mg to treat Female Pattern Hair Loss, as well as their use of PRP injections for further hair growth.

community I am a dermatologist with a clinical interest in alopecia. AMA

in Will treatment work for me? 2 years ago

In this conversation, 4990 discussed various treatments for hair loss, including oral minoxidil, PRP, transplan, Jak inhibitors, Dutasteride, Finasteride, Olumiant, Ketoconazole, RU58841, microneedling, baricitinib, and CCCA. They recommended scalp biopsies in unclear cases of DUPA, twice weekly to twice daily shampooing for topical minoxidil users, and two sessions spaced one month apart with follow up at month three to determine the effectiveness of PRP treatment.

community can someone please tell me its going to get better? im bawling my eyes out

in Female 67 upvotes 2 years ago

A 16-year-old girl is experiencing hair loss, which has worsened despite using minoxidil and multivitamins. Suggestions include broader hormone testing and considering other treatments like spironolactone if the hair loss is due to androgenic alopecia.

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research Investigation of Four Novel Male Androgenetic Alopecia Susceptibility Loci: No Association with Female Pattern Hair Loss

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