Apoptosis in Follicles of Individuals with Female Pattern Hair Loss Is Associated with Perifollicular Microinflammation

May 2016 in “ International Journal of Cosmetic Science ”

Pablo Ramos, Gabrielli Brianezi, Alfredo Martins, M. Fátima C. Guedes da Silva, M. Matilde Marques, Hélio Amante Miot

apoptosis hair follicles female pattern hair loss perifollicular microinflammation inflammation follicle miniaturization cell death FPHL

Studysummary This study found that apoptosis was more prevalent in hair follicles of women with female pattern hair loss, particularly in miniaturized follicles, and was associated with follicular inflammation. Our plain-language summary of this paper — not a Tressless recommendation.

This study found that apoptosis (cell death) in hair follicles of individuals with female pattern hair loss (FPHL) is associated with perifollicular microinflammation. The study involved 17 women with FPHL and five controls, and showed that inflammation can lead to apoptosis and play a role in the pathogenesis of follicle miniaturization. The study highlights the importance of understanding the role of inflammation in FPHL and the need for further research to confirm this mechanism.

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Research cited in this study

8 / 8 results

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research Hair Through the Female Life Cycle

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This study suggests that low proliferation rates in bald areas of androgenetic alopecia patients, along with persistent inflammatory infiltrate, may lead to follicular miniaturization and fibrosis.

research Effects of Finasteride on Apoptosis and Regulation of the Human Hair Cycle

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This study suggests that finasteride may affect hair follicle growth by altering the expression of caspases and XIAP, potentially regulating the anagen phase of hair growth.

research Androgenetic Alopecia and Microinflammation

131 citations , August 2000 in “International Journal of Dermatology”

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research Diagnostic and Predictive Value of Horizontal Sections of Scalp Biopsy Specimens in Male Pattern Androgenetic Alopecia

309 citations , May 1993 in “Journal of The American Academy of Dermatology”

This study concluded that horizontal sections of scalp biopsy specimens provide more diagnostic information for male pattern androgenetic alopecia than vertical sections and can predict hair regrowth potential following topical minoxidil therapy.