The Action of a Cosmetic Hair Treatment on Follicle Function

March 2018 in “ bioRxiv (Cold Spring Harbor Laboratory) ”

G. A. Turner, Paterson Se, Baines Fl, Andrew E. Mayes, Reilly Dm, Hudson Nm, Tony Dadd, A.K. Majumdar, Rinky Kapoor, Jieruo Gu, Needhi Bhalla, Fang Xu

Dynagen zinc salts hair growth fiber diameter follicle-cell proliferation plucking force claudin-1 protease activity Dynagen TM

TLDR The hair treatment made hair grow faster and thicker and strengthened the hair roots.

The document reports on a series of studies that investigated the effects of a new leave-on hair treatment (LOT) containing Dynagen TM and zinc salts on hair growth. The studies involved healthy women aged 18–65 and used various methods to assess the LOT's impact on hair growth rate, fiber diameter, follicle-cell proliferation, and plucking force. Results showed that the LOT significantly increased hair growth rate, fiber diameter, bundle cross-sectional area, and the plucking force required to remove hair, indicating stronger follicular root structure. Additionally, Dynagen was found to increase claudin-1 expression in cultured follicles, and zinc salts reduced protease activity. Overall, the Dynagen-based LOT was concluded to enhance hair-fiber diameter and growth rate, as well as strengthen the hair follicle.

View this study on biorxiv.org →

Discuss this study in the Community →

Cited in this study

16 / 16 results

research Androgenetic Alopecia: An Update Of Treatment Options

110 citations , August 2016 in “Drugs”

Minoxidil is the only FDA-approved topical drug for treating male or female pattern hair loss, and other medications like finasteride and dutasteride can also increase hair growth.

research Trichotillometry: A Technique for Hair Assessment

4 citations , March 2015 in “Skin Research and Technology”

Trichotillometry is a reliable method to measure hair strength and assess hair loss treatments.

research Differential Effects of Caffeine on Hair Shaft Elongation, Matrix and Outer Root Sheath Keratinocyte Proliferation, and Transforming Growth Factor-β2/Insulin-Like Growth Factor-1-Mediated Regulation of the Hair Cycle in Male and Female Human Hair Follicles In Vitro

60 citations , October 2014 in “British Journal of Dermatology”

Caffeine affects hair growth and health differently in men and women.

research The Thinning Top: Why Older People Have Less Hair

4 citations , August 2014 in “Journal of Investigative Dermatology”

Old people have less hair because their hair follicles don't regenerate as well, not because of fewer stem cells, and a protein called follistatin might help reactivate hair growth.

research A Randomized, Active- and Placebo-Controlled Study of the Efficacy and Safety of Different Doses of Dutasteride Versus Placebo and Finasteride in the Treatment of Male Subjects with Androgenetic Alopecia

97 citations , March 2014 in “Journal of The American Academy of Dermatology”

Dutasteride 0.5 mg works better than finasteride and placebo for increasing hair in men with hair loss.

research Phototrichogram Analysis of Normal Scalp Hair Characteristics with Aging

16 citations , November 2013 in “European Journal of Dermatology”

Hair gets thinner and grayer with age, and density decreases more in men on top and in women on top and back.

research Protease Activity, Localization, and Inhibition in the Human Hair Follicle

11 citations , October 2013 in “International Journal of Cosmetic Science”

The study suggests that a new protease inhibitor can make hair harder to pull out, potentially reducing hair loss.

research What Women Want: Quantifying the Perception of Hair Amount - An Analysis of Hair Diameter and Density Changes with Age in Caucasian Women

61 citations , July 2012 in “British Journal of Dermatology”

Caucasian women's hair appears thickest in their 20s, with perceived thinning after mid-30s due to both decreasing density and diameter.

research The Keratins of the Human Beard Hair Medulla: The Riddle in the Middle

87 citations , January 2010 in “The journal of investigative dermatology/Journal of investigative dermatology”

Human beard hair medulla contains a unique and complex mix of keratins not found in other human tissues.

research Male Pattern Baldness: Current Treatments, Future Prospects

40 citations , September 2008 in “Drug Discovery Today”

Current treatments for male pattern baldness include minoxidil and finasteride, with new options being developed.

research The Cross-Section Trichometer: A New Device for Measuring Hair Quantity, Hair Loss, and Hair Growth

29 citations , July 2008 in “Dermatologic Surgery”

The Cross-section Trichometer is a new tool that can measure hair quantity and detect hair loss and growth.

research Characteristic Features of Japanese Women's Hair With Aging and Hair Loss

76 citations , February 2007 in “Journal of Dermatological Science”

Japanese women typically start experiencing hair loss after 40, with reduced hair density and thickness being the main factors.

research The Lack of Significant Changes in Scalp Hair Follicle Density With Advancing Age

33 citations , April 2005 in “British Journal of Dermatology”

Aging alone barely affects the number of hair follicles, meaning hair loss is minimal without other conditions like androgenetic alopecia.

research The First Clinical Trial of Topical Application of Procyanidin B-2 to Investigate Its Potential as a Hair Growing Agent

26 citations , June 2001 in “PTR. Phytotherapy research/Phytotherapy research”

Procyanidin B-2 lotion might help men grow thicker hair without side effects.

research Diffuse Hair Loss: Causes, Diagnosis, and Treatment

83 citations , May 1999 in “International Journal of Dermatology”

Hair loss that spreads out can often fix itself or be treated by finding and handling the cause.

research Photographic Documentation of Hair Growth in Androgenetic Alopecia

102 citations , October 1996 in “Dermatologic Clinics”

Photographic documentation crucial for evaluating hair growth in androgenetic alopecia.

5 / 5 results

research Autologous Whole Fat Injection Stimulates Hair Growth in Resistant Androgenetic Alopecia: Report of Nine Cases

3 citations , August 2021 in “Journal of Cosmetic Dermatology”

Fat injections can help regrow hair in stubborn hair loss cases.

research Hair Loss (Alopecia or Baldness)

June 2018

Baldness is often hereditary and linked to male hormones, becoming noticeable when half the hair is lost.

research Treatments of Hereditary Hair Loss (Alopecia)

April 2018

Some treatments like minoxidil, finasteride, and surgery can help with hereditary hair loss.

research Dermo-Follicular Proliferation Induced by Paclitaxel and Counteracted by Minoxidil in Mice

January 2011

Minoxidil and a solvent mixture can prevent hair loss caused by chemotherapy in mice.

research Towards a Molecular Understanding of Hair Loss and Its Treatment

236 citations , July 2001 in “Trends in Molecular Medicine”

Future hair loss treatments should aim to extend hair growth, reactivate resting follicles, reverse shrinkage, and possibly create new follicles, with gene therapy showing promise.