Dermo-Follicular Proliferation Induced by Paclitaxel and Counteracted by Minoxidil in Mice

Alopecia was induced in mice using Paclitaxel, a chemotherapy drug known to cause hair follicle miniaturization and inhibit hair growth cycles. To counteract this, Minoxidil, a vasodilator, was used, which helps stop hair loss and promotes hair follicle proliferation by improving blood flow and nutrient delivery. The study found that administering a solvent mixture (Ethanol:PEG:Water) alongside Paclitaxel prevented alopecia. Additionally, groups treated with crude extract or Minoxidil along with Paclitaxel did not exhibit hair loss. Quantitative data, such as A/T ratio and follicular density, supported the inhibition of alopecia.