Effects of Substance P on the Expression of Various Factors to Control Hair Growth in Human Hair Follicle Culture

January 2004 in “ Linchuang pifuke zazhi ”

Tak-Heon Oh, Eun Young Lee, Won‐Soo Lee

Substance P hair growth human hair follicles dermal papilla cells anagen phase FGF-7 caspase-3 IL-1β

Studysummary This study found that while SP did not enhance linear hair growth in cultured hair follicles, it prolonged the anagen phase and altered the expression of growth factors and apoptosis-related molecules, suggesting a stimulatory effect on hair growth.

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The study investigated the effects of Substance P (SP) on hair growth in cultured human hair follicles and dermal papilla cells. SP did not significantly affect the rate of linear hair growth but did prolong the anagen phase of the hair cycle. In hair follicles, SP increased the expression of the hair growth factor FGF-7 and decreased the expression of the apoptosis-related molecule caspase-3. Additionally, SP reduced the expression of the hair growth-inhibitory factor IL-1β. These findings suggested that SP had a growth-stimulatory effect, particularly by extending the anagen phase, and influenced hair growth at the molecular level.

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