LB821 Human Hair Follicle Dermal Papilla as an In Vitro Model to Study Stress-Induced Hair Growth Arrest

    August 2021 in “ Journal of Investigative Dermatology ”
    G. Dellacqua A. Richards
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    TLDR Stress causes hair loss by making the body produce cortisol, which stops hair cells from growing.
    The study "LB821 Human hair follicle dermal papilla as an in vitro model to study stress-induced hair growth arrest" investigates the role of stress in hair loss, specifically Telogen Effluvium. The research found that stress activates the HPA axis within the human hair follicle, leading to the secretion of cortisol, which is linked to hair growth arrest. The study used human hair follicle dermal papilla cells (HFDPC) and cortisol as the stressor to investigate potential therapeutics for stress-induced hair loss. The results showed a significant, non-cytotoxic, proliferation arrest in HFDPC when exposed to cortisol. The study also found a strong upregulation of DKK1 and PAI-1 genes and inhibition of WNT10A, VEGFa, POMC, and SFRP5 genes. The researchers concluded that cortisol is a good inducer for stress-induced growth arrest models in vitro and will further test ingredients to modulate this mechanism.
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