Effect of PRP on the Proliferation of Dermal Papilla Cells and Hair Follicle Regeneration in Mice
March 2013
in “
PubMed
”
New to Platelet-Rich Plasma? There is a guide in the encyclopedia. Read the guide → Studysummary This study found that applying 10% platelet-rich plasma significantly increased hair follicle density and reduced the time for hair formation in a mouse model compared to no PRP treatment. Our plain-language summary of this paper — not a Tressless recommendation.
The study investigated the effects of platelet-rich plasma (PRP) on dermal papilla cells (DPCs) and hair follicle regeneration in mice. PRP was prepared and applied to DPCs, and its proliferative effect was measured using MTT assay. The study found that activated PRP significantly increased the proliferation and aggregative growth of DPCs. In the reconstituted skin area, 10% PRP resulted in a higher yield of hair follicles (344 +/- 27) compared to 0% PRP (288 +/- 35), with a 19.4% increase in hair follicle density. Additionally, 10% PRP shortened the time of hair formation to 18 +/- 1 days compared to 20 +/- 1 days with 0% PRP. The study concluded that PRP had a considerable effect on both the time of hair formation and the yield of hair follicle reconstitution.
