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GlossaryProopiomelanocortin (POMC)

precursor protein cleaved into hormones affecting pigmentation and stress

Proopiomelanocortin (POMC) is a large precursor protein that is produced in the pituitary gland and other tissues. It is cleaved into several important hormones, including adrenocorticotropic hormone (ACTH), which regulates cortisol production, and melanocyte-stimulating hormones (MSH), which influence skin pigmentation and hair growth.

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research Genome-Wide Analysis Reveals the Molecular Basis of Genetic Variation of Important Economic Traits in Cashmere Goats on Qinghai-Tibet Plateau

2 citations , August 2023 in “The Journal of Animal and Plant Sciences”

Genetic analysis of Cashmere goats identified key genes for wool, reproduction, and high-altitude adaptation.

research The Local Hypothalamic–Pituitary–Adrenal Axis in Cultured Human Dermal Papilla Cells

9 citations , June 2020 in “BMC Molecular and Cell Biology”

Stress hormone CRF can cause hair loss by affecting hair growth cells and hormones.

research Involvement of the Central Hypothalamic-Pituitary-Adrenal Axis in Hair Growth and Melanogenesis Among Different Mouse Strains

6 citations , October 2018 in “PLoS ONE”

Stress can slow hair growth and affect skin color by impacting the body's stress response system.

research Investigation of Hub Genes and Immune Infiltration in Androgenetic Alopecia Using Bioinformatics Analysis

November 2022 in “Annals of Translational Medicine”

Immune activities and specific genes are important in male pattern baldness.

research An Integrative View of Mammalian Seasonal Neuroendocrinology

85 citations , May 2019 in “Journal of neuroendocrinology”

The article concludes that better understanding gene regulation related to seasonal changes can offer insights into the mechanisms of seasonal timing in mammals.

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