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GlossaryProopiomelanocortin (POMC)

precursor protein cleaved into hormones affecting pigmentation and stress

Proopiomelanocortin (POMC) is a large precursor protein that is produced in the pituitary gland and other tissues. It is cleaved into several important hormones, including adrenocorticotropic hormone (ACTH), which regulates cortisol production, and melanocyte-stimulating hormones (MSH), which influence skin pigmentation and hair growth.

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research The Skin POMC System (SPS): Leads and Lessons from the Hair Follicle

66 citations , October 1999 in “Annals of the New York Academy of Sciences”

The Skin POMC System affects hair growth and skin responses to stress.

research Spatiotemporal Expression, Distribution, and Processing of POMC and POMC-Derived Peptides in Murine Skin

49 citations , July 2000 in “Journal of Histochemistry & Cytochemistry”

POMC-derived peptides are important for skin functions like immune response and stress management.

research Human Hair Follicles Display a Functional Equivalent of the Hypothalamic-Pituitary-Adrenal (HPA) Axis and Synthesize Cortisol

489 citations , June 2005 in “The FASEB Journal”

Human hair follicles can produce cortisol like the body's stress response system.

Melanogenesis Is Coupled to Murine Anagen: Toward New Concepts for the Role of Melanocytes and the Regulation of Melanogenesis in Hair Growth

research Melanogenesis Is Coupled to Murine Anagen: Toward New Concepts for the Role of Melanocytes and the Regulation of Melanogenesis in Hair Growth

210 citations , July 1993 in “The journal of investigative dermatology/Journal of investigative dermatology”

Hair color production in mice is closely linked to the hair growth phase and may also influence hair growth itself.

research The Human Skin as a Hormone Target and an Endocrine Gland

146 citations , January 2004 in “Hormones”

Human skin acts like a hormone-producing organ, making and managing various hormones important for skin and hair health.

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