research Role of plasminogen activator inhibitor type 1 (PAI-1) in PCOS patient
This study found that women with PCOS had significantly elevated plasma levels of PAI-1, which correlated with insulin resistance and obesity.
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research Oral contraceptive pill (OCP) treatment alters the gene expression of intercellular adhesion molecule-1 (ICAM-1), tumor necrosis factor-α (TNF-α), monocyte chemoattractant protein-1 (MCP-1) and plasminogen activator inhibitor-1 (PAI-1) in polycystic ovary syndrome (PCOS) women compared to drug-naive PCOS women
In this study, oral contraceptive use in women with PCOS increased the expression of certain inflammatory gene markers, which were positively associated with metabolic abnormalities.
research Deletion of adipocyte Sine Oculis Homeobox Homolog 1 prevents lipolysis and attenuates skin fibrosis
This study suggests that targeting the increased expression of SIX1 in systemic sclerosis may be a viable strategy for addressing dermal fibrosis.
research Ku80 as a Novel Receptor for Thymosin β4 That Mediates Its Intracellular Activity Different from G-actin Sequestering
This study found that increased intracellular expression of thymosin β4 is necessary and sufficient to induce PAI-1 gene expression in endothelial cells, potentially mediated through Ku80 as a novel receptor.
research Wound healing in development
This review discusses the developmental regulation of wound healing mechanisms in mammals, focusing on the role of the Wnt and TGF‐β signaling pathways, and reports no new clinical findings.
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5 / 7 resultscommunity How ET-02 Works. Also no proof that it's better than Minoxidil. At least for now.
ET-02, a PAI-1 inhibitor, is not proven to be more effective than Minoxidil for hair loss. Other treatments like finasteride, dutasteride, PP405, and AMP-303 are also discussed, focusing on cellular senescence and oxidative stress.
community What happened with verteporfin?
Verteporfin, combined with microneedling, shows promise for hair regrowth by allowing hair follicles to grow in wounds, but it's expensive and painful. Pai-1 inhibitors may also help prevent hair loss by degrading fibrosis, and some users continue using minoxidil alongside these treatments.
community ICYMI: Eirion ET-02’s Successful Phase 1 Trial Results for Androgenic Alopecia Treatment
ET-02 showed significant hair growth in five weeks, outperforming minoxidil, with a non-hormonal mechanism that avoids side effects of treatments like finasteride. A phase 2 trial is planned to further assess ET-02's efficacy and safety.
community Why does Pelage PP405 receive so much attention, while Eirion ET-02 seems to be almost forgotten?
ET-02 is seen as promising for addressing hair loss and graying, but PP405 is more advanced in development and has better publicity. Some users plan to use both treatments alongside minoxidil and dutasteride.
community Eirion Therapeutics Announces Potential Breakthrough Treatment for Hair Loss Based on First-in-Man Clinical Trial Results
ET-02, a new hair loss treatment, shows promising results with a 6-fold increase in hair count, potentially outperforming minoxidil by activating stem cells in hair follicles. Further trials are ongoing to confirm its efficacy and safety, with potential market release in the future.
Clinics
6 / 37 results- 53Hair Loss TreatmentsHair TransplantPAI Medical Hair RestorationRegina, SK · CA
- 13
Hair TransplantHair Loss TreatmentsPAI MedicalOttawa, ON · CA - 51Hair SystemsPAI Medical ClevelandCleveland, OH · US
- 18Hair SystemsPAI Medical KingstonKingston, ON · CA
- 15Hair TransplantPAI Medical OttawaOttawa, ON · CA
- 52
Hair TransplantHair Loss TreatmentsSMPWe Grow Hair - PAI Medical GroupBrentwood, TN · US
Experts
6 / 17 results
85Hair Transplant SurgeonDr. Jamuna Pai, MD
Vadodara, Gujarat, India
34DermatologistDr. Ravish Pai, MD, MBBS, FRGUHS, FAGE
Bengaluru, Karnataka, India
70TrichologistDhanya Sunil Pai, BAMS, FMC
Thrissur, Kerala, India
- 88Hair Transplant Surgeon
Dr. Vivek M. Pai, MD, MBBS, DNB
Bengaluru, Karnataka, India
78Hair Transplant SurgeonDr. Guilherme Paiva Monti, MD
Barueri, SP, Brazil
68Hair Transplant SurgeonDr. Rodrigo Paiva
Zona 1, PR, Brazil
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