The Hair Loss Encyclopedia

Effects of Epidermal Growth Factor on Human Hair Follicle Growth In Vitro

April 2000 in “ Chinese Journal of Dermatology ”

Shuxia Yang, Zhihong Zhong, Jian Qin, Shengqing Ma

TLDR Epidermal growth factor (EGF) boosts hair follicle growth and speeds up hair cycle transition.

The study investigated the effects of epidermal growth factor (EGF) on human hair follicle growth in vitro. Human hair follicles were cultured and divided into an EGF-treated group and a control group. Results showed that EGF significantly increased hair shaft and follicle elongation from day 1 to day 3 compared to the control group. Histological analysis revealed thickening of the lower outer root sheath and formation of a club hair-like structure in the EGF-treated group. Additionally, 3H-leucine incorporation indicated higher radioactivity in the hair follicle epithelium of the EGF-treated group, suggesting that EGF stimulated hair follicle epithelium growth and induced premature transition from anagen to catagen phase.

View this study on en.cnki.com.cn →

Discuss this study in the Community →

Related Research

11 / 11 results

Autologous Activated Platelet-Rich Plasma in Hair Growth: A Pilot Study in Male Androgenetic Alopecia with In Vitro Bioactivity Investigation

research Autologous Activated Platelet-Rich Plasma in Hair Growth: A Pilot Study in Male Androgenetic Alopecia with In Vitro Bioactivity Investigation

4 citations , September 2020 in “Journal of Cosmetic Dermatology”

PRP treatment significantly increased hair density and thickness in male hair loss.

research Influences of IGF-1 and EGF on Primary Hair Follicles of Liaoning Cashmere Goat In Vitro

1 citations , January 2010 in “Shenyang Nongye Daxue xuebao”

IGF-1 and EGF together significantly boost hair follicle growth in cashmere goats.

research Culture of Free Hair Follicles from Ovine Skin on Williams E Serum-Free Medium

January 2008 in “Anhui nongye kexue”

Mongolia sheep hair follicles grew well in a serum-free medium for 19 days.

research Effects of IGF-I and EGF on In Vitro Growth of Hair Follicles of Sheep

January 2006

IGF-I and EGF together boost sheep hair follicle growth.

research Effects of Substance P on the Expression of Various Factors to Control Hair Growth in Human Hair Follicle Culture

1 citations , January 2004 in “Linchuang pifuke zazhi”

Substance P helps hair growth by extending the growth phase and affecting certain growth factors.

research Keratin 14 in Skin and Hair Follicle of Rats During Postnatal Development Period

January 2001 in “Acta Academiae Medicine Militaris Tertiae”

K14 expression in young rats differs from adults.

research Histological Study of Reconstructed Hair Follicles

August 2000 in “Chinese Journal of Dermatology”

Dermal papilla cells can successfully grow and maintain hair follicles.

Hair Follicle Elongation in Organ Culture of Skin from Newborn and Adult Mice

research Hair Follicle Elongation in Organ Culture of Skin from Newborn and Adult Mice

23 citations , May 1998 in “Journal of Dermatological Science”

Insulin or IGF-I is needed for hair growth in newborn mice, while minoxidil helps adult mouse hair grow, suggesting a way to study human hair loss.

Effects of Epidermal Growth Factor on the Morphology and Patterns of DNA Synthesis in Isolated Human Hair Follicles

research Effects of Epidermal Growth Factor on the Morphology and Patterns of DNA Synthesis in Isolated Human Hair Follicles

94 citations , February 1994 in “The journal of investigative dermatology/Journal of investigative dermatology”

EGF makes hair follicles grow longer but stops hair production.

research Regulation of Hair Follicle Development: An In Vitro Model for Hair Follicle Invasion of Dermis and Associated Connective Tissue Remodeling

30 citations , July 1993 in “Journal of Investigative Dermatology”

research Distribution of Epidermal Growth Factor Receptors in Rat Tissues During Embryonic Skin Development, Hair Formation, and the Adult Hair Growth Cycle

112 citations , August 1984 in “Journal of Investigative Dermatology”