TLDR Epidermal growth factor (EGF) boosts hair follicle growth and speeds up hair cycle transition.
The study investigated the effects of epidermal growth factor (EGF) on human hair follicle growth in vitro. Human hair follicles were cultured and divided into an EGF-treated group and a control group. Results showed that EGF significantly increased hair shaft and follicle elongation from day 1 to day 3 compared to the control group. Histological analysis revealed thickening of the lower outer root sheath and formation of a club hair-like structure in the EGF-treated group. Additionally, 3H-leucine incorporation indicated higher radioactivity in the hair follicle epithelium of the EGF-treated group, suggesting that EGF stimulated hair follicle epithelium growth and induced premature transition from anagen to catagen phase.
4 citations
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September 2020 in “Journal of Cosmetic Dermatology” PRP treatment significantly increased hair density and thickness in male hair loss.
1 citations
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January 2010 in “Shenyang Nongye Daxue xuebao” IGF-1 and EGF together significantly boost hair follicle growth in cashmere goats.
January 2008 in “Anhui nongye kexue” IGF-I and EGF together boost sheep hair follicle growth.
1 citations
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January 2004 in “Linchuang pifuke zazhi” January 2001 in “Acta Academiae Medicine Militaris Tertiae” K14 expression in young rats differs from adults.
August 2000 in “Chinese Journal of Dermatology” Dermal papilla cells can successfully grow and maintain hair follicles.
23 citations
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May 1998 in “Journal of Dermatological Science” Insulin or IGF-I is needed for hair growth in newborn mice, while minoxidil helps adult mouse hair grow, suggesting a way to study human hair loss.
94 citations
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February 1994 in “The journal of investigative dermatology/Journal of investigative dermatology” EGF makes hair follicles grow longer but stops hair production.
30 citations
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July 1993 in “Journal of Investigative Dermatology” 112 citations
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August 1984 in “Journal of Investigative Dermatology”