Histological Study of Reconstructed Hair Follicles

    August 2000 in “ Chinese Journal of Dermatology ”
    Lu Zhang, Jinjin Wu, Liu Rongqin, Baiyu Zhong, Shuqian Tang
    TLDR Dermal papilla cells can successfully grow and maintain hair follicles.
    The study investigated the potential of dermal papilla cells (DPC) to induce hair follicle regeneration and reconstruction. Using type I collagen gels populated with different cell types, including DPC, dermal sheath cells (DSC), and dermal fibroblasts, the researchers cultured these with epithelial cells from hair follicles. The results showed that hair follicle-like structures formed in cultures combining DPC with various follicle cells, and relatively intact hair follicles developed when these cultures were implanted into the subcutis of nude mice. The study concluded that DPC could effectively induce and sustain hair follicle growth both in vivo and in vitro.
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