Hair Follicle Regeneration by Injection of Follicular Cells

The objective of this study was to investigate the mechanisms of hair follicle regeneration by injecting follicular cells isolated from mouse skin. The researchers peeled off the epidermis and digested the dermis to isolate hair follicles. These follicles were then digested into dissociated cells and injected into the skin of nude mice. The results showed that after injection, a cyst formed containing various cells and tissues. Over time, the skin thickened and hair follicles formed, accompanied by an increase in blood vessels. After several weeks, a cyst containing black hairs formed at the injection site. The study concluded that follicular cells can spontaneously aggregate and develop into hair follicles with a normal growth cycle after implantation. The success of regeneration depends on the interactions between follicular cells, recipient sites, and cell numbers.