Hair Follicle Units Improving the Construction of Tissue Engineered Skin In Vitro

January 2013 in “ Journal of Tissue Engineering and Reconstructive Surgery ”

Jing Weimin

hair follicle units tissue-engineered skin dermis rat tail tendon collagen type I fibroblasts keratinocytes skin appendages sebaceous glands HE staining basement membrane laminin collagen IV stratified epidermis cornified epidermis differentiation markers hair follicles collagen skin glands epidermis

TLDR Inserting hair follicle units improved the development of tissue-engineered skin.

The study aimed to enhance tissue-engineered skin by incorporating isolated hair follicle units. Researchers inserted these units into engineered dermis composed of rat tail tendon collagen type I, fibroblasts, and keratinocytes. After 4 weeks, the tissue-engineered skin developed skin appendages, including hair follicles and sebaceous glands, as confirmed by HE staining. The presence of a continuous basement membrane and expression of laminin and collagen IV were observed, indicating successful integration. Keratinocytes on the tissue formed a stratified and cornified epidermis, expressing differentiation markers. The study concluded that inserting hair follicle units promoted the differentiation and maturation of tissue-engineered skin, suggesting a novel approach for constructing such skin.

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