The Formation of Hair Follicle Induced by Immortalized Human Dermal Papilla Cell Line In Vivo

January 2011 in “ The Chinese Journal of Dermatovenereology ”

Jinjin Wu

immortalized human dermal papilla cell line DPC-hTERT hair follicle formation hair follicle epithelial cells keratin dermal papilla cells

TLDR DPC-hTERT cells can create hair follicle-like structures.

The study investigated the ability of the immortalized human dermal papilla cell line, DPC-hTERT, to induce hair follicle formation in vivo. Researchers co-injected DPC-hTERT cells at passage 30 with freshly isolated hair follicle epithelial cells into nude mice. The results showed that this combination formed hair follicle-like structures that expressed hair follicle-specific keratin. The conclusion was that DPC-hTERT retained the normal function of dermal papilla cells and could induce hair follicle-like structures in vivo.

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Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

community Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

in Research 865 upvotes 1 year ago

The treatment for androgenetic alopecia involves using finasteride and minoxidil with intense exercise and cold exposure to boost metabolism and reduce androgenic effects, potentially leading to hair regrowth. This approach may activate biological pathways for improved hair and overall health.

community Minoxidil is NOT an Anti-androgen. No.

in Research/Science 43 upvotes 1 week ago

Minoxidil is not an anti-androgen; it is a growth stimulator and does not lower DHT like finasteride or dutasteride. Minoxidil can cause side effects like facial swelling and anxiety due to its vasodilator properties.

community Why is nobody studying the difference between donor and balding hair?

in Chat 89 upvotes 1 year ago

The conversation discusses why the difference between donor and balding hair isn't studied more to find a cure for hair loss. Treatments mentioned include Minoxidil, finasteride, and RU58841.

community Upcoming treatment ideas in the future

in Research/Science 11 upvotes 1 year ago

Exploring future hair loss treatments, including immunosuppressants for hair transplants and hair cloning, with a focus on leveraging research from other medical fields. Current treatments like finasteride and minoxidil are effective for most, but there's a call for more funding and innovation in the hair loss industry.

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research Generation of Hair Follicle Germs In Vitro Using Human Postnatal Skin Cells

2 citations , January 2020 in “Methods in molecular biology”

Scientists created early-stage hair follicles from human skin cells, which could help treat baldness and study hair growth.

research Hair Follicle Generation by Injections of Adult Human Follicular Epithelial and Dermal Papilla Cells into Nude Mice

15 citations , July 2017 in “PubMed”

Injecting a mix of human skin and hair cells into mice can grow new hair.

research Review of Hair Follicle Dermal Cells

321 citations , December 2009 in “Journal of Dermatological Science”

Dermal cells are key in controlling hair growth and could potentially be used in hair loss treatments, but more research is needed to improve hair regeneration methods.