Hair Follicle Generation by Injections of Adult Human Follicular Epithelial and Dermal Papilla Cells into Nude Mice

In the 2017 study involving 15 C57BL/6 nude mice, researchers found that injecting a combination of cultured adult human dermal papilla cells and hair epithelial cells could induce hair growth. The mice were divided into three groups, with one group receiving dermal papilla cells, another receiving a mixture of both cell types, and a control group receiving a placebo. Histopathologic examination and PKH tracing confirmed hair growth and the presence of transplanted cells in the new hair, respectively. The group injected with the mixture showed visible hair growth, while the group with only dermal papilla cells did not show detectable hair follicles. This suggests a potential new treatment for hair loss in humans, especially for non-scarring alopecia. The study was supported by Tehran University of Medical Sciences and Royan Institute, with no conflicts of interest reported.