Study on Biologic Characteristics of Cultured Dermal Papilla Cells and Hair Follicle Regeneration In Vitro and In Vivo

    January 2006 in “ Chinese Journal of Dermatology ”
    Zheng Mi
    TLDR Cultured dermal papilla cells can regenerate hair follicles and sustain hair growth.
    The study observed that cultured dermal papilla cells (DPCs) were capable of inducing hair follicle regeneration and sustaining hair growth both in vitro and in vivo. It was found that the expression of endothelin-1 (ET-1) and stem cell factor (SCF) was strong in early passages of DPCs but diminished after 6 passages. Hair follicle-like structures were successfully formed in organotypic cultures and when implanted into nude mice, intact hair follicles were observed. The ability of DPCs to induce hair follicle regeneration was positively correlated with the expression levels of ET-1 and SCF.
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