Exposure to Gamma-Rays at the Telogen Phase of the Hair Cycle Inhibits Hair Follicle Regeneration at the Anagen Phase in Mice

    November 2013 in “ International Journal of Radiation Biology ”
    Kimihiko Sugaya, Tomohisa Hirobe
    Image of study
    TLDR Gamma-rays exposure during the resting phase of hair growth can damage hair regeneration and color in mice.
    In 2014, Kimihiko Sugaya and Tomohisa Hirobe conducted a study on 115 mice to examine the effects of gamma-rays on hair follicle regeneration. They found that exposure to gamma-rays during the telogen (resting) phase of the hair cycle led to decreased hair follicle density and the induction of curved hair follicles in the subsequent anagen (growth) phase. This was accompanied by pigmentation anomalies, such as white hair and hypopigmented hair bulbs. These effects were dose-dependent, with even a relatively low dose of 0.5 Gy of gamma-rays affecting hair follicle regeneration. The study concluded that gamma-rays damage stem cells and progenitors for keratinocytes and melanocytes, thereby affecting the structure and character of regenerated hair follicles.
    Discuss this study in the Community →

    Research cited in this study

    7 / 7 results

    Related Community Posts Join

    6 / 12 results

      community I just made my own PRP - DIY PRP

      in Research/Science  549 upvotes 1 year ago
      The post and conversation are about a user who made their own Platelet-Rich Plasma (PRP) for hair loss treatment at home, using their own blood and a centrifuge. The responses vary, with some users supporting the DIY approach to save money, others expressing concern about the safety and effectiveness of the method, and a few joking about the lengths people will go to combat hair loss.
      Diffuse hair loss and scalp biopsies

      community Diffuse hair loss and scalp biopsies

      in Research  692 upvotes 3 months ago
      Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

      community The Worst Hair Loss Condition You (MAY) have: LPP

      in Research/Science  43 upvotes 2 months ago
      Lichen Planopilaris (LPP) is an autoimmune condition causing permanent hair loss and fibrosis, often misdiagnosed. Treatments include pioglitazone, topical corticosteroids, anti-inflammatory medication, and Jak inhibitors.

      community Vitamin E

       20 upvotes 5 years ago
      Vitamin E was discussed as a treatment for hair shedding, with a specific form mentioned. A user shared a link to a study and started taking the Vitamin E variants used.

    Related Research

    5 / 5 results