Effects of TNF-Alpha and Minoxidil on Human Hair Growth In Vitro

January 2003 in “ Journal of Clinical Dermatology ”

Tae-Gyun Lim, Jeong-Hun Park, Gwang Seong Choi

TNF-alpha minoxidil hair follicles in vitro model Rogaine

TLDR TNF-${\alpha}$ slows hair growth, and minoxidil doesn't help.

The study investigated the effects of TNF-${\alpha}$ and minoxidil on human hair growth using an in vitro model. It found that TNF-${\alpha}$ inhibited the rate of linear hair growth in cultured hair follicles, while minoxidil did not stimulate hair growth nor protect against the growth inhibition caused by TNF-${\alpha}$. This suggested that TNF-${\alpha}$ had a growth-inhibitory effect on hair follicles, and minoxidil did not counteract this effect.

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community NMN Promotes Cell Proliferation and Hair Growth by Reducing Oxidative Stress

in Research/Science 14 upvotes 6 months ago

NMN shows promise in promoting hair growth by reducing oxidative stress and weakening androgens. It may be a beneficial addition to hair loss treatments like Minoxidil and Finasteride.

community UPDATE: The theory that explains everything. Please help me make this big!

in Research/Science 449 upvotes 3 years ago

Hair loss theory involves 3alpha-hydroxysteroid reductase (3AHD) converting DHT to androstenol. Discussion explores potential treatments and encourages more research.

community Diffuse hair loss and scalp biopsies

in Research 692 upvotes 4 months ago

Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

community What is the real impact of dutasteride on neurosteroids? A little review of 2 scientific datas

in Research/Science 21 upvotes 5 months ago

Dutasteride at 0.5 mg/day does not significantly alter allopregnanolone levels, but higher doses (2.5 mg/day) do. Dutasteride may also have anti-neuroinflammatory effects, but the impact on neurosteroids is still debated.

community The MPB itch aka DHT itch is very real.

in Chat 9 upvotes 1 year ago

Hair loss itch is caused by DHT attacking follicles and stimulating nerves. Finasteride users who respond well don't experience this itch.

community 3 months. Dut, Min, Keto, Vitamin D, exercise

in Progress Pictures 353 upvotes 2 years ago

A user's experience using dutasteride, minoxidil, ketoconazole, vitamin D, scalp massage, exercise, and avoiding vaping and 2-in-1 shampoo/conditioner to treat hair loss; they also discussed the side effects of finasteride.

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8 / 8 results

research 6-Gingerol Inhibits Hair Shaft Growth in Cultured Human Hair Follicles and Modulates Hair Growth in Mice

17 citations, February 2013 in “PLOS ONE”

6-Gingerol, found in ginger, may slow down hair growth and could be used for hair removal.

research Minoxidil Activates β-Catenin Pathway in Human Dermal Papilla Cells: A Possible Explanation for Its Anagen Prolongation Effect

88 citations, February 2011 in “Journal of Dermatological Science”

Minoxidil helps hair growth by activating the β-catenin pathway.

Effects of TNF-Alpha and Minoxidil on Human Hair Growth In Vitro

Related Community Posts Join

community NMN Promotes Cell Proliferation and Hair Growth by Reducing Oxidative Stress

community UPDATE: The theory that explains everything. Please help me make this big!

community Diffuse hair loss and scalp biopsies

community What is the real impact of dutasteride on neurosteroids? A little review of 2 scientific datas

community The MPB itch aka DHT itch is very real.

community 3 months. Dut, Min, Keto, Vitamin D, exercise

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