6-Gingerol Inhibits Hair Shaft Growth in Cultured Human Hair Follicles and Modulates Hair Growth in Mice

    February 2013 in “ PLOS ONE ”
    Yong Miao, Yabin Sun, Wenjun Wang, Bo Du, Shuyu Xiao, Yijue Hu, Zhiqi Hu
    Image of study
    TLDR 6-Gingerol, found in ginger, may slow down hair growth and could be used for hair removal.
    The study from 2013 found that 6-gingerol, the main active component of ginger, actually inhibits hair growth rather than promoting it as traditionally believed. In vitro tests showed that 6-gingerol decreased the Bcl-2/Bax ratio in human dermal papilla cells, leading to cell apoptosis and suppressed hair shaft elongation in cultured human hair follicles. In vivo experiments with mice demonstrated that 6-gingerol prolonged the telogen phase and delayed hair regrowth. The study concluded that 6-gingerol has the potential to be used as a hair removal agent. The research involved 180 hair follicles from 3 volunteers and 36 female C57BL/6 mice, but noted the need for further research due to the small sample size.
    Discuss this study in the Community →

    Research cited in this study

    11 / 11 results

    Related Community Posts Join

    6 / 1000+ results

      community 6 months before and after pics: VDPHL01 (oral minoxidil)

      in Progress Pictures  92 upvotes 1 day ago
      A user shared their positive experience with a clinical trial for a new oral medication, VDPHL01, which is a reformulated version of oral minoxidil taken at a high dose of 17mg daily, showing significant hair regrowth after six months. The user noted that this formulation is believed to be more effective and time-released, with fewer side effects compared to regular oral minoxidil.

      community 6 months progress happy so far

      in Progress Pictures  319 upvotes 2 weeks ago
      The user reported significant hair growth progress after six months using daily Dutasteride 0.5mg and oral Minoxidil 5mg. Many users expressed amazement and inquired about side effects, age, and product brands.

      community 6 month update on DUT AND minoxidil

      in Progress Pictures  69 upvotes 3 weeks ago
      The user has been using a regimen of dutasteride (DUT) and topical minoxidil (1ml once a day) for six months, resulting in hair regrowth and increased thickness. The user reports no side effects and mentions that the shedding phase lasted about a month.

      community 6 Month Progress Update - Long Journey

      in Progress Pictures  477 upvotes 3 weeks ago
      Significant hair regrowth was achieved over six months using minoxidil, finasteride, microneedling, biotin and collagen shampoo, and MSM powder. The user feels more confident and may consider a hair transplant if necessary.

    Related Research

    5 / 5 results